Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0021-v3Release info

Latest

Research title

Genetic Analysis in Psychiatric Disorders

Research overview

Aims: Identify genes relevant to bipolar disorder
Methods: Whole exome sequence analysis using Illumina HiSeq 2000/2500
Participants/materials: Three pairs of healthy monozygotic twins, 66 trios with bipolar disorder proband and unaffected parents
URL: https://www.juntendo-molecular-psychiatry.com/en/ (opens in a new tab)

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000014	NGS (Exome)	WES	Controlled-access (Type I)	2020-09-28
	JGAD000379	NGS (Exome)	WES	Controlled-access (Type I)	2021-03-04

Data provider

Principal investigator: Tadafumi Kato
Affiliation: RIKEN Brain Science Institute

Research projects

Name	URL
Laboratory of Molecular Dynamics of Mental Disorders	https://www.juntendo-molecular-psychiatry.com/en/ (opens in a new tab)

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Challenging Exploratory Research	Search for genetic mutations by next generation sequencing of monozygotic twins discordant for bipolar disorder.	21659277
Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED)	Integrated research for the realization of genome medicine of mental disorders	JP18km0405208
Strategic Research Program for Brain Sciences, Japan Agency for Medical Research and Development (AMED)	Identification of genetically defined subsets of bipolar disorder by trio sequencing.	JP20dm0107133

Related publications

Title	DOI	Dataset ID
Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations.	https://doi.org/10.1038/mp.2016.69 (opens in a new tab)	JGAD000379
Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder	https://doi.org/10.1038/s41467-021-23453-w (opens in a new tab)	JGAD000379

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Hailiang Huang	Stanley Center, the Broad Institute	Massachusetts, United States	Asian Bipolar Genetics Network (A-BIG-NET)	2021-08-12 – 2024-08-29	JGAD000014 JGAD000379
Masahiro Nakatochi	Public Health Informatics Unit Department of Integrated Health Sciences, Nagoya University	Japan	Research on elucidation of susceptibility to brain and mental diseases (vulnerability to disease onset) and efficacy and side effects of drugs (treatment responsiveness) through genetic analysis	2023-03-08 – 2025-10-27	JGAD000379