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Aims: Identify genes relevant to bipolar disorder
Methods: Whole exome sequence analysis using Illumina HiSeq 2000/2500
Targets: Three pairs of healthy monozygotic twins, 66 trios with bipolar disorder proband and unaffected parents
Dataset ID | Access type | Type of data | Release date | |
|---|---|---|---|---|
| JGAD000014 | Controlled-access (Type I) | NGS (Exome) | 2020-09-28 | |
Name | URL |
|---|---|
| Laboratory of Molecular Dynamics of Mental Disorders | https://mdmd.riken.jp/en/ |
Name | Title | Project number |
|---|---|---|
| KAKENHI Grant-in-Aid for Challenging Exploratory Research | Search for genetic mutations by next generation sequencing of monozygotic twins discordant for bipolar disorder. |
|
| Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED) | Integrated research for the realization of genome medicine of mental disorders |
|
| Strategic Research Program for Brain Sciences, Japan Agency for Medical Research and Development (AMED) | Identification of genetically defined subsets of bipolar disorder by trio sequencing. |
|
Title | DOI | Datasets |
|---|---|---|
| Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations. | https://doi.org/10.1038/mp.2016.69 | |
| Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder | https://doi.org/10.1038/s41467-021-23453-w | |
Name | Organiation | Country | Research title | Period of data use | Datasets |
|---|---|---|---|---|---|
| Huang Hailiang | the Broad Institute | USA | Asian Bipolar Genetics Network (A-BIG-NET) | 2021-08-12—2024-08-29 | |
| Nakatochi Masahiro | Nagoya University | Japan | Research on elucidation of susceptibility to brain and mental diseases (vulnerability to disease onset) and efficacy and side effects of drugs (treatment responsiveness) through genetic analysis | 2023-03-08—2025-10-27 | |