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Dataset ID

NHA000205

Type of data
GWAS for myasthenia gravis
Access criteria
Unrestricted-access
Total data volume
230 MB
File formats
  • DOCX
  • ZIP
Research
hum0197
Date published
2026-01-22
Date modified
2026-01-22
Secondary ID
hum0197.v29.MG-gwas.v1

Unrestricted-access files linked to this dataset

Download the URL list
FileLabelSizeCopy URL
Dictionary_hum0197_v29.docxDictionary file19.4 KB
hum0197.v29.MG-gwas.v1.zip230 MB

Analysis method

genome wide SNPs

Materials and participants
myasthenia gravis (ICD10: G70.0): 1,434 cases (Japan MG Registry)
control participants: 42,913 (BioBank Japan)
  • Health status
    Mixed
  • Subject count
    44,347 (Individual)
  • Cohort
    BioBank Japan, Japan MG Registry
Disease
myasthenia gravis (G700)
Sample description
DNAs extracted from peripheral blood cells
  • Tissue
    Peripheral blood
  • Tumor / normal
    Normal
Sample provider
N/A
Experimental method
Genotyping by array
Target
N/A
Reagent kit
Infinium Asian Screening Array Kit
Platform
Illumina Infinium Asian Screening Array
QC and filtering
Sample QC: We excluded individuals with low genotyping call rates (call rate < 98%). We included samples of the estimated Japanese ancestry using PCA.
Variant QC: We excluded variants with (1) genotyping call rate < 99%, (2) minor allele count < 5, (3) P-value for Hardy-Weinberg equilibrium < 1.0 × 10−10, and (4) > 5% allele frequency difference compared with the imputation reference panel.
Post-imputation QC: We excluded imputed variants with Rsq < 0.5 and minor allele frequency < 0.5%
Imputation
Haplotype phasing: SHAPEIT4
Imputation: Minimac4
Analysis method
Genotyping: GenomeStudio
SAIGE
Variant count
9,034,566 variants
Processed data type
GWAS summary statistics
Data use policy
NBDC data sharing policy (JGAP000001)