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Dataset ID

NHA000203

Type of data
Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Access criteria
Unrestricted-access
Total data volume
1.2 TB
File formats
  • TXT
  • XLSX
Research
hum0197
Date published
2025-10-27
Date modified
2025-10-27
Secondary ID
hum0197.v26.374-traits.v1

Unrestricted-access files linked to this dataset

Download the URL list
Per page
20
2050100

3161–3180 / 8930

FileLabelSizeCopy URL
BBJ1.metabolome.S_VLDL_FC_by_CE.European_cuisine.txt.gz53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Ever_drinking.txt.gz53.9 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Ever_smoking.txt.gz53.9 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Japanese_cuisine_Washoku.txt.gz53.7 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Joint_all_environments.txt.gz120 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Joint_commonly_tested_environments.txt.gz86.4 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Physical_activity.txt.gz53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Sex.txt.gz53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct.Age.txt.gz53.1 MB
BBJ1.metabolome.S_VLDL_FC_pct.Combined.txt.gz32.3 MB
BBJ1.metabolome.S_VLDL_FC_pct.Current_smoking.txt.gz53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Dairy_products.txt.gz53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct.European_cuisine.txt.gz53.5 MB
BBJ1.metabolome.S_VLDL_FC_pct.Ever_drinking.txt.gz53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Ever_smoking.txt.gz53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Japanese_cuisine_Washoku.txt.gz53.7 MB
BBJ1.metabolome.S_VLDL_FC_pct.Joint_all_environments.txt.gz120 MB
BBJ1.metabolome.S_VLDL_FC_pct.Joint_commonly_tested_environments.txt.gz86.4 MB
BBJ1.metabolome.S_VLDL_FC_pct.Physical_activity.txt.gz53.5 MB
BBJ1.metabolome.S_VLDL_FC_pct.Sex.txt.gz53.6 MB

3161–3180 / 8930

Analysis method

genome wide SNPs

Materials and participants
BioBank Japan (n=166,757), UK Biobank (n=273,453)
(ICD 10: E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J30.2)
no. Phenotypes: 374
  • Health status
    Mixed
  • Subject count
    440,210 (Individual)
  • Cohort
    BioBank Japan, UK Biobank
  • Population
    British, Japanese
Disease
Type 2 diabetes mellitus (E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J302)
Sample description
DNAs extracted from peripheral blood cells
  • Tissue
    Peripheral blood
  • Tumor / normal
    Normal
Sample provider
N/A
Experimental method
Genotyping by array
Target
N/A
Reagent kit
HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform
Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
QC and filtering
Clinical Phenotypes: imputation quality > 0.7, minor allele frequency (MAF) > 0.01, autosomal variants
Metabolome: further restricted to (i) genotyped variants, (ii) HapMap3 variants, and (iii) the variants with P_G×E < 1.0×10^-7 in BBJ or UKBB for at least one of the clinical traits
Imputation
BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
Analysis method
GEM
Variant count
BBJ: 7,444,735 (Clinical traits)
1,009,566 (Metabolome)
UK Biobank: 9,813,264 (Clinical traits)
1,478,430 (Metabolome)
Phenotype data
Included
Data use policy
NBDC data sharing policy (JGAP000001)