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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Dataset ID

NHA000159

Type of data
NGS (NAT2 haplotype)
Access criteria
Unrestricted-access
Total data volume
9.6 KB
File formats
  • XLSX
  • ZIP
Research
hum0163
Date published
2021-02-09
Date modified
2021-02-09
Secondary ID
hum0163.v2.nat2.v1

Unrestricted-access files linked to this dataset

Download the URL list
FileLabelSizeCopy URL
hum0163.v2.nat2.v1.zip323 B
hum0163_header.xlsxDictionary file9.3 KB

Analysis method

Targeted DNA sequencing

Materials and participants
990 patients with psychiatric/neurological disorders or cancers
- epilepsy (ICD10: G402) / bipolar disorder (ICD10: F319): 343 cases (receiving lamotrigine)
- schizophrenia (ICD10: F209): 454 cases
- breast cancer (ICD10: C509): 65 cases (receiving trastuzumab)
- colorectal cancer (ICD10: C189): 83 cases (receiving regorafenib)
- malignant melanoma (ICD10: C439): 45 cases (receiving nivolumab)
  • Health status
    Affected
  • Subject count
    990 (Individual)
Disease
epilepsy (G402)
/ bipolar disorder (F319)
schizophrenia (F209)
breast cancer (C509)
colorectal cancer (C189)
malignant melanoma (C439)
Sample description
DNAs extracted from peripheral blood cells
  • Tissue
    Peripheral blood
  • Tumor / normal
    Mixed
Sample provider
N/A
Experimental method
Targeted DNA sequencing
Target
diplotype of coding regions of 100 pharmacogenes (1846 variants), CYP2D6 gene and NAT2 gene
Reagent kit
In-house multiplex PCR
Fragmentation
N/A
Platform
Illumina MiSeq
Read type
Paired-end
Read length
250 bp
Data use policy
NBDC data sharing policy (JGAP000001)