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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Dataset ID

JGAD000315

Type of data
NGS (Target Capture)
Access criteria
Controlled-access (Type I)
Total data volume
239 GB
File formats
  • FASTQ
Research
hum0222
Date published
2020-09-28
Date modified
2020-11-18
DDBJ Search
JGAD000315 (opens in a new tab)
JGA Study
JGAS000224 (opens in a new tab)

Unrestricted-access files linked to this dataset

Download the URL list
FileLabelSizeCopy URL
119genes_including_known_causal_genes_of_HBOC.xlsx119 genes10.4 KB

Analysis method

Targeted DNA sequencing

Materials and participants
breast cancer (ICD10: C50): 115 cases (124 samples)
primary tumor tissues and paired blood: 108 cases (116 samples)
primary tumor tissues only: 7 cases (8 samples)
  • Health status
    Affected
  • Subject count
    124 (Sample)
Disease
breast cancer (C50)
Sample description
DNAs extracted from primary tumor tissues and peripheral blood cells
  • Tissue
    Breast, Peripheral blood
  • Tumor / normal
    Mixed
Sample provider
N/A
Experimental method
Targeted DNA sequencing
Target
119 genes including known causal genes of HBOC syndrome
(BRCA1, BRCA2, STK11, NBN, ATM, CHEK2, PALB2,
TP53, PTEN, CDH1, RAD51D, RAD51C, BRIP1, RAD50,
XRCC2, RAD51B, NF1, EPCAM, MLH1, MSH2, MSH6,
PMS2, BARD1, MRE11A, FANCC, BLM, FAM175A,
RINT1, FANCM, RECQL, etc.)
Reagent kit
KAPA HyperPlus Kit
SureSelect Custom
Fragmentation
blood 108 samples : Ultrasonic fragmentation (Covaris)
tumor 49 samples : Ultrasonic fragmentation (Covaris)
tumor 75 samples : Enzymatic fragmentation (DNase included in KAPA HyperPlus Kit)
Platform
Illumina HiSeq 2000
Read type
Paired-end
Read length
101 bp
Data use policy
NBDC data sharing policy (JGAP000001)