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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0607-v1Release info

Latest

Research title

Exploratory Biomarker Study Associated with the Investigator-Initiated Clinical Trial of Alectinib for Rare Cancers Harboring ALK Alterations

Research overview

Aims
To identify biomarkers associated with the clinical efficacy of alectinib treatment by performing omics analyses of specimens, including tumor tissue and peripheral blood samples collected before and after investigational treatment, as well as circulating tumor cells (CTCs), from patients with rare cancers harboring ALK gene alterations who were enrolled in an investigator-initiated clinical trial of alectinib and received alectinib treatment.
Methods
Target sequencing
Participants/materials
cfDNA in 24 plasma samples obtained from 24 patients enrolled in an investigator-initiated clinical trial of alectinib for rare cancers harboring ALK alterations, and gDNA extracted from buffy coats from 19 of these patients.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001104NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)

Data provider

Principal investigator
Shinji Kohsaka
Affiliation
Division of Cellular Signaling, National Cancer Center Research Institute

Research projects

NameURL
TACKLE trial translational research
N/A

Grants

NameTitleProject number
NCC Research Grant
Development of Clinical Sequencing Using Advanced Technologies and Validation of Its Feasibility and Clinical Utility
  • 2025-A-04

Related publications

TitleDOIDataset ID
Efficacy and Safety of Alectinib in Pediatric and Adult Patients with ALK-Altered Advanced Solid Tumors: a phase II TACKLE Trial (NCCH1712/MK003)

Controlled access users

No use of the controlled access data has been recorded.