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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0588-v1Release info

Latest

Research title

Development of Disease Models and Cell Transplantation Therapies through the Optimization of Precise Genome Engineering in Human iPS Cells

Research overview

Aims
By engineering the genome, we will introduce mutations in genes into iPS cells to model cardiomyopathy.
Methods
Total RNA extracted by using of the RNeasy Mini Kit (Qiagen, 74104) was used for RNA-seq analysis.
Participants/materials
HPS0076 (409B2), an iPS cell line derived from a healthy individual, in its undifferentiated state and after differentiation into cardiomyocytes. The undifferentiated state and after differentiation into cardiomyocytes of tetraploid iPS cells established by cell fusion of HPS0076 and WTC11. Three independent RNA extractions for each condition.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001067NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2026-07-16

Data provider

Principal investigator
Yuichiro Miyaoka
Affiliation
Tokyo Metropolitan Institute of Medical Science

Research projects

NameURL
Regenerative Medicine Project

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidating the Significance of Cell Type-Specific Ploidy Using iPSC Models
  • 24K02028
KAKENHI Grant-in-Aid for Challenging Research (Exploratory)
Flexible gene exchange method between human iPS cell lines like mouse breeding
  • 24K21954
Japan Cardiovascular Research Foundation, The Bayer Scholarship for Cardiovascular Research
iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates Cardiomyocyte Tetraploidization
N/A
SENSHIN Medical Research Foundation
Tetraploid iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates the In Vivo Heart
N/A
TERUMO Life Science Foundation
Transforming Regenerative Medicine Using iPSC-Derived Cardiomyocytes That Recapitulate
N/A

Related publications

TitleDOIDataset ID
Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs
https://doi.org/10.1038/s42003-026-10763-2 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.