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Research ID

hum0585-v1Release info

Latest

Research title

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Research overview

Aims
Using genome editing, we introduced mutations in genes associated with cardiomyopathy into iPS cells to model cardiomyopathy. We also tested iPS cells established from multiple individuals.
Methods
RNA-seq
Participants/materials
WTC11, an iPS cell line derived from a healthy individual, established at the Gladstone Institutes in its undifferentiated state and after differentiation into cardiomyocytes. The undifferentiated state and after differentiation into cardiomyocytes of tetraploid iPS cells established by fusing WTC11 cells.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
DRA029128NGS (RNA-seq)
  • RNA-seq
Unrestricted-access2026-06-18

Data provider

Principal investigator
Yuichiro Miyaoka
Affiliation
Tokyo Metropolitan Institute of Medical Science

Research projects

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidating the Significance of Cell Type-Specific Ploidy Using iPSC Models
  • 24K02028
KAKENHI Grant-in-Aid for Challenging Research (Exploratory)
Flexible gene exchange method between human iPS cell lines like mouse breeding
  • 24K21954
Japan Cardiovascular Research Foundation, The Bayer Scholarship for Cardiovascular Research
iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates Cardiomyocyte Tetraploidization
N/A
SENSHIN Medical Research Foundation
Tetraploid iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates the In Vivo Heart
N/A
TERUMO Life Science Foundation
Transforming Regenerative Medicine Using iPSC-Derived Cardiomyocytes That Recapitulate
N/A

Related publications

TitleDOIDataset ID
Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs
https://doi.org/10.1038/s42003-026-10763-2 (opens in a new tab)