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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0563-v1Release info

Latest

Research title

"Elucidation of Immune Status and Its Clinical Significance in Patients with Solid Tumors, Including Gastrointestinal Cancers": A Phase II Clinical Trial of Lenvatinib Plus Pembrolizumab in Patients with Advanced Gastric Cancer

Research overview

Aims
Analysis of somatic mutational burden and immune-related gene expression to elucidate the detailed mechanisms of anti-tumor immune responses.
Methods
Whole exome sequencing, RNA sequencing
Participants/materials
gastric cancer
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001038NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2026-04-16

Data provider

Principal investigator
Shohei Koyama
Affiliation
Department of Immuno genomic medicine, National Cancer Center

Research projects

NameURL
Macrophage Reprogramming in Gastric Cancer
N/A

Grants

NameTitleProject number
Moonshot Research and Development Program, Japan Agency for Medical Research and Development (AMED)
Actualization of a cancer-free society through regulation of chronic inflammation
  • JP22zf0127009
Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Development (AMED)
Development of a novel immunotherapeutic strategy with sustained therapeutic effect by modulating the priming phase
  • JP23ama221329
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Establishment of molecular target-immune integrated therapy targeting immunosuppressive molecules on cancer cells.
  • JP23ck0106796
National Cancer Center Research and Development Fund
Establishment of specimen banking and comprehensive analysis platforms for advanced immunogenomic profiling
  • 2024-A-03

Related publications

TitleDOIDataset ID
Lenvatinib combined with PD-1 blockade therapy benefits gastric cancers through immunosuppressive macrophage modulation
https://doi.org/10.1158/2326-6066.cir-25-0982 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.