Research ID

hum0519-v1Release info

Latest

Research title

Detailed analysis of antigen specificity in autoimmune diseases

Research overview

Aims: In patients with autoimmune diseases, it is known that immune cells react against components of their own body. By identifying and characterizing immune cells that respond to self-antigens - components that should normally be absent or rendered immunologically inert - we aim to elucidate the mechanisms underlying autoimmune pathology and contribute to the advancement of medical science.
Methods: Single cell RNA sequencing/TCR repertoire analyses
Participants/materials: Labial salivary gland tissue obtained from patients with Sjögren's syndrome who tested positive for anti-SSA antibodies
URL: N/A

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000950	NGS (scRNA-seq/TCR repertoire)	scRNA-seq + scTCR-seq	Controlled-access (Type I)	2026-02-10

Data provider

Principal investigator: Masaru Takeshita
Affiliation: Division of Rheumatology, Keio University

Research projects

No research projects.

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Early-Career Scientists	Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseases	20K17430
KAKENHI Grant-in-Aid for Scientific Research (C)	Elucidation of the Mechanisms of Autoantibody Production at Lesion Sites in Autoimmune Diseases	22K08528
JSR・JKiC Next-generation Project	Establishing Disease Control Methods Through Detailed Analysis of Antigen Specificity in Autoimmune Diseases	N/A
Keio University Academic Promotion Fund	Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases and Development of Antigen-Specific Immunosuppressive Therapies	N/A
Keio University Fukuzawa Memorial Fund	Comprehensive Understanding of Autoimmunity and Practical Application of Antigen-Specific Immunosuppressive Therapies	N/A
Keio University Next-Generation Research Promotion Program	Comprehensive Analysis of Salivary Gland Lesions as Sites of Autoimmune Responses	N/A
Mochida Memorial Foundation for Medical and Pharmaceutical Research - Research Grant -	lucidation of Autoimmune Mechanisms in Lesional Tissues of Sjögren's Syndrome and Development of Antigen-Specific Immunosuppressive Therapies	N/A
Kowa Life Science Foundation - Research Grant -	Elucidation of Molecular Mechanisms Involved in Autoimmune Responses at Lesion Sites in Sjögren's Syndrome	N/A
Takeda Science Foundation - Medical Research Grant -	Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases	N/A
The Astellas Foundation for Research on Metabolic Disorders - Research Grant -	Identification of molecular targets involved in autoimmune responses in autoimmune diseases	N/A
The SENSHIN Medical Research Foundation - Research Grant -	Development of autoantigen-specific immunosuppressive therapy for Sjögren's Disease	N/A
The Nakatomi Foundation - Research Grant -	Creation of Artificial Synovium Using Synovial Fibroblasts Derived from Rheumatoid Arthritis	N/A
The Takahashi Industrial Economic Research Foundation - Research Grant -	Development of Autoantigen-Specific Immunosuppressive Therapy for autoimmune disease	N/A
The Waksman Foundation of Japan INC - Research Grant -	Molecular Pathogenesis Analysis of Autoimmune Diseases from Both Autoimmunity and Inflammation Perspectives	N/A
Okinaka Memorial Institute for Medical Research	Elucidation of the molecular mechanisms involved in maintaining autoimmunity	N/A

Related publications

No related publications.

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000950