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Research ID

hum0508-v1Release info

Latest

Research title

Elucidation of the pathogenesis of ocular diseases and exploration of therapeutic strategies using disease-specific iPS cells

Research overview

Aims
We will establish disease-specific iPS cells from patient somatic cells and induce them into an ocular developmental model system to mimic the ocular developmental stage in vitro, and conduct detailed analysis of the phenotype and cell population obtained at the time of differentiation induction, which is extrapolated to the normal stage of formation of major organs. This research will help to elucidate the pathogenesis of the disease and to search for therapeutic methods. This research is expected to elucidate the detailed pathogenesis and mechanisms of ocular diseases that have remained unexplored until now.
Methods
single-cell RNA-seq
Participants/materials
Epithelial tissues were collected from the clear central corneal region and the limbus of a patient with congenital aniridia during cultivated oral mucosal epithelial transplantation (COMET) surgery. The tissues were obtained by gentle scraping using a scalpel.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000932NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2025-05-21

Data provider

Principal investigator
Kohji Nishida
Affiliation
Department of Ophthalmology, Graduate School of Medicine, Osaka University

Research projects

No research projects.

Grants

NameTitleProject number
Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)
Stem cell system-based four dimensional ocular tissue remodeling in homeostatic and pathological states
  • JP18gm1210004
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)
Elucidation of pathogenesis and development of therapeutics in aniridia using disease-specific iPS cells
  • JP22bm0804021

Related publications

TitleDOIDataset ID
Transcriptional landscape of aniridia-associated keratopathy through single-cell RNA sequencing
https://doi.org/10.1016/j.jtos.2025.05.008 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.