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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0500-v1Release info

Latest

Research title

Elucidation of factors involved in the progression of diabetic kidney disease

Research overview

Aims
In recent years, it has become apparent that there are cases where kidney function declines rapidly from the stage of microalbuminuria without high-grade proteinuria (rapid decliner), which is different from the classic course of diabetes, and this has become a problem.In addition, a new concept of diabetic kidney disease has been proposed as a more comprehensive disease concept for chronic kidney disease associated with diabetes.The factors and molecular mechanisms that determine the course of diabetic nephropathy, whether it is the classic diabetic nephropathy or the rapid decliner, are unknown.In order to develop effective diagnostic and therapeutic methods for individual cases and conditions of diabetic nephropathy patients, it is necessary to elucidate the molecular mechanisms.
Methods
single-cell RNA-seq
Participants/materials
Male patients aged 20 to 75 years with a history of diabetes for more than 10 years, an eGFR of less than 60 mL/min/1.73m² at their most recent outpatient visit, who were taking a RAS inhibitor but not a SGLT2 inhibitor and were scheduled to undergo a renal biopsy.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000944NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2026-05-15

Data provider

Principal investigator
Hiromichi Wakui
Affiliation
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine

Research projects

NameURL
Elucidating factors associated with the progression of diabetic kidney disease
N/A

Grants

No grants.

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.