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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0483-v1Release info

Latest

Research title

Request for cooperation regarding collection and distribution of human specimens and research using clinical information

Research overview

Aims
The Keio Women's Health Biobank, established by the Department of Obstetrics and Gynecology at Keio University School of Medicine, contributes to medical research by providing gynecologic tumor-derived organoids, along with associated clinical information, multi-omics data, and drug sensitivity profiles, to domestic and international research institutions and pharmaceutical companies.
Methods
Whole exome sequencing, RNA sequencing
Participants/materials
Ovarian cancer
Exome: Ovarian clear cell carcinoma: 11 cases (tumor-derived organoid: 11 samples, normal tissue: 11 samples)
RNA-seq: Ovarian clear cell carcinoma: 10 cases (tumor-derived organoid: 10 samples, AGR2 knockout clear cell carcinoma organoid: 4 samples, GFP overexpressed clear cell organoid as control: 2 samples)
High-grade serous carcinoma: 7 cases (tumor-derived organoid: 7 samples)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000905NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2025-06-11

Data provider

Principal investigator
Tatsuyuki Chiyoda
Affiliation
Department of Obstetrics and Gynecology, Keio University School of Medicine

Research projects

NameURL
Therapeutic Development for Ovarian Cancer / Clinical Oncology and Clinical Genetics Lab
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Early-Career Scientists
Development of Nucleic Acid Therapeutics Targeting Small RNA-mRNA Networks in Ovarian Cance
  • 19K18651
KAKENHI Grant-in-Aid for Scientific Research (B)
Development of Curative Treatment for Refractory Ovarian Cancer Using Omics Analysis of Ovarian Cancer Organoid Banks
  • 21H03079
KAKENHI Grant-in-Aid for Early-Career Scientists
Overcoming PARP Inhibitor Resistance Acquisition - Utilizing BRCA1/2 Mutant Organoids -
  • 21K16822

Related publications

TitleDOIDataset ID
High-throughput drug screening of clear cell ovarian cancer organoids reveal vulnerability to proteasome inhibitors and dinaciclib and identify AGR2 as a therapeutic target
https://doi.org/10.1158/2767-9764.CRC-25-0024 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Noriomi MatsumuraObstetrics and Gynecology, Kindai UniversityJapanIntegrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR12024-10-15 – 2027-12-31
Ken YamaguchiGynecology and Obstetrics, Kyoto UniversityJapanIntegrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR12024-10-22 – 2027-12-31