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Research ID

hum0467-v1Release info

Latest

Research title

Genetic background of the development of pelvic organ prolapse

Research overview

Aims
To clarify the genetic background behind the onset of pelvic organ prolapse (POP), enable identification of high-risk groups, and provide early therapeutic intervention.
Methods
Samples were devided into four groups (1~4) based on study groups (BioBank Japan: BBJ, Okinawa Bio-information Bank: OBi, and POP registry: POP) and Japanese sub-populations (Hondo, Ryukyu). Associations studies for POP were analyzed in each group and meta-analysis was performed.
Participants/materials
[Case] female participants with a medical history of POP. Total 771 patients (BBJ n = 447, POP n = 324)
[Control] female participants with no history of POP or general population. Total 76,625 individuals (BBJ: n =73,892, OBi: n = 2,733)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000194GWAS for POP
  • Genotyping by array (GWAS)
Unrestricted-access2024-10-02

Data provider

Principal investigator
Shiro Maeda
Affiliation
Faculty of Medicine, University of the Ryukyus

Research projects

No research projects.

Grants

NameTitleProject number
Project for Whole Implementation to Support and Ensure the Female Life (Wise), Japan Agency for Medical Research and Development (AMED)
Stratification of patients with pelvic organ prolapse or lower urinary tract diseases based on comprehensive information and goals of individualized treatment strategies
  • JP22gk0210025
Promotion project of innovation-eco system collaborating organization from the Okinawa prefecture
Disease Genome Research and Genomic Medicine for the Health and Longevity of Okinawans
N/A

Related publications

TitleDOIDataset ID
Genome-wide association studies for pelvic organ prolapse in the Japanese population
https://doi.org/10.1038/s42003-024-06875-2 (opens in a new tab)