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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0456-v1Release info

Latest

Research title

Molecular Pathological exprolation of Tumor Formation and Functional Differentiation Using Parasellar Skull Base Tumors and Malignant Glioma Tissues

Research overview

Aims
Comprehensive analysis of genetic and clinical information on parasellar base skull tumors and multiple malignant gliomas is expected to elucidate the pathogenesis of the diseases and provide clinically useful results leading to prevention and the development of personalized medicine.
Methods
The cell suspension from the resected tumor specimens was processed according to 10×Genomics specifications, using the 10×Chromium Next GEM single-cell 3ʹ reagent kit and library construction kit. After quantification and quality assessment of the library, single-cell RNA sequencing was performed on the NovaSeq 6000.
Participants/materials
Surgical resection specimens from 10 craniopharyngiomas
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000855NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2024-07-19

Data provider

Principal investigator
Tatsuma Matsuda
Affiliation
Department of Molecular Diagnosis, Graduate School of Medicine Chiba University

Research projects

NameURL
Molecular Pathological exprolation of Tumor Formation and Functional Differentiation Using Parasellar Skull Base Tumors and Malignant Glioma Tissues
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Fundamental research on age-related long non-coding RNAs in functional alterations associated with adipose and vascular tissue ageing
  • 21H02974
KAKENHI Grant-in-Aid for Scientific Research (B)
Molecular pathological research on obesity and diabetes based on analysis of mitochondrial complexes and regulatory mechanisms
  • 19H03708
KAKENHI Grant-in-Aid for Scientific Research (B)
Regulation of chromatin function and iPS reprogramming by the p53 transcription factor complex
  • 22300325

Related publications

TitleDOIDataset ID
Deciphering craniopharyngioma subtypes: Single-cell analysis of tumor microenvironment and immune networks
https://doi.org/10.1016/j.isci.2024.111068 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.