HumanDBs

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NBDC Research ID:hum0455-v3

Release info

Latest

Research title

Explore genetic abnormalities, molecular targets, predictive of drug sensitivity, histomorphology, and biomarkers in lung cancerAnalysis of genetic abnormalities and their biological significance in lung cancer

Research overview

Aims: Small cell carcinoma and large cell neuroendocrine carcinoma (LCNEC) fall under high-grade neuroendocrine carcinomas (HGNEC). HGNEC, characterized by poor prognosis and high treatment resistance, presents subtypes withinSCLC based on ASCL1, NEUROD1, POU2F3, and YAP1 expression levels, each influencing prognosis differently. LCNEC exhibits heterogeneous distribution of these factors, hypothesized to contribute to treatment resistance. Incorporating whole-genome sequencing and spatial transcriptomics, we'll investigate this variability. Leveraging tumor tissue morphology, we'll analyze single-cell factor expression correlations and gene expressions in the microenvironment, aiming to identify new HGNEC therapeutic targets and understand treatment resistance.

Methods: Whole-genome sequencing, High-performance in situ gene expression mapping Xenium (10x Genomics), Visium Spatial Gene Expression data (10X Genomics), Single-cell RNA sequencing data derived from nuclei (10X Genomics), STOMICS spatial transcritome data (BGI)

Targets: Samples from 10 + 10 + 13 patients with pulmonary neuroendocrine carcinoma operated on at the University of Tsukuba and Jichi Medical University Hospital

Datasets

Dataset ID	Access type	Type of data	Release date
JGAD000865	Controlled-access (Type I)	NGS (WGS)	2025-08-08
JGAD000926	Controlled-access (Type I)	NGS (WGS)	2026-02-20
JGAD000974	Controlled-access (Type I)	NGS (WGS: PromethION) NGS (WGS: Novaseq 6000) Xenium In Situ Gene Expression NGS (Visium Spatial Gene Expression), Histological image NGS (snRNA-seq) NGS (STOmics)	2026-04-10
JGAD000866	Controlled-access (Type I)	Xenium In Situ Gene Expression	2025-08-08

Data provider

Principal investigator: Daisuke Matsubara
Name: Department of diagnostic pathology, The university of Tsukuba

Research projects

Name	URL
No data

Grants

Name	Title	Project number
Project for Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Development (AMED)	Study of heterogeneity of genomic and epigenomic aberrations and association with microenvironment in lung cancer tissues	JP24ama221522

Related publications

Title	DOI	Dataset ID
Clinicopathologic, Cellular, and Molecular Analyses of Pulmonary Neuroendocrine Carcinoma With High Expression of Hepatocyte Nuclear Factor 4 Alpha	https://doi.org/10.1016/j.labinv.2025.104210	JGAD000865 JGAD000866

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
No data