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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0430-v1Release info

Latest

Research title

Construction of endoscopic biopsy banking for understanding the intestinal environment in colorectal diseases and exploratory studies using these banking systems.

Research overview

Aims
Colorectal cancer is the most common type of cancer in Japan. Although some colorectal cancers have a genetic background, most colorectal cancers are sporadic. Known risk factors for colorectal cancer include smoking, obesity, lack of exercise, and intake red or processed meat. Furthermore, although it has been suggested that changes in the intestinal environment due to changes in diet and lifestyle may be involved in the increased incidence of colorectal cancer in Japan, the molecular mechanism has not yet been fully elucidated. The main objective of this study is to elucidate the changes in the intestinal environment that cause colorectal tumors.
Methods
Research biopsies were obtained from the tumor, normal mucosa 1-2 cm away from the tumor, terminal ileum, cecum, ascending colon, descending colon, and sigmoid colon to rectum using a lower gastrointestinal endoscopy for participants. DNA/RNA was extracted from the samples and used for RNA-seq and whole exome sequencing analyses.
Participants/materials
RNA-seq: 14 patients with advanced colorectal cancer, 41 patients with early stage colorectal cancer, 6 patients with colorectal adenoma, and 17 healthy individuals
Exome: 24 patients with advanced colorectal cancer (including 14 same cases in RNA-seq), 23 patients with early stage colorectal cancer (including 20 same cases in RNA-seq)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000785NGS (RNA-seq, Exome)
  • RNA-seq
  • WES
Controlled-access (Type I)2025-12-04

Data provider

Principal investigator
Shinichi Yachida
Affiliation
Division of Cancer Genomics, National Cancer Center Research Institute

Research projects

NameURL
Establishment of an Endoscopic Biopsy Repository for Comprehensive Characterization of the Gut Microenvironment in Colorectal Diseases and Its Application to Exploratory Translational Research
N/A

Grants

NameTitleProject number
National Cancer Center Research and Development Fund
Establishment of a comprehensive metagenomic database of the gut microbiota in colorectal cancer patients and individuals at high risk for cancer development: A multi-institutional collaborative study
  • 2020-A-4
National Cancer Center Research and Development Fund
Establishment of the infrastructure for a multicenter biobank of fecal and comprehensive gastrointestinal endoscopic biopsy specimens
  • 2023-A-6
KAKENHI Grant-in-Aid for Scientific Research (B)
Development of target-selective mid-size drugs using cyclic peptide derivatives
  • 20H03362
KAKENHI Grant-in-Aid for Scientific Research (B)
Studies on the elucidation of intestinal environmental changes in colorectal tumorigenesis via the serrated pathway
  • 23H02892
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Research aimed at elucidating alterations in the intestinal microenvironment associated with colorectal cancer development in high-risk individuals, and the development of personalized preventive strategies based on these findings
  • JP22ck0106546
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Development of personalized colorectal cancer prevention strategies through integrated profiling of the gut microbiome using stool and endoscopic biopsy specimens in ultra-high-risk populations
  • JP23ck0106799
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Research and development aimed at predicting the occurrence of adverse effects associated with anticancer drugs through comprehensive analysis of the gut microbiota
  • JP21cm0106477
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED)
Development of biomarkers for early detection and susceptibility assessment of young-onset colorectal cancer through comprehensive analysis of the intestinal microenvironment
  • JP23ama221404
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED)
Elucidation of the pathogenetic mechanisms underlying early-onset colorectal cancer through integrated analyses of diet, gut microbiota, and mucosal inflammation, and the development of novel susceptibility and early diagnostic strategies
  • JP24ama221430
Research Program on the challenges of Global Health issues, Japan Agency for Medical Research and Development (AMED)
Investigation of infection-associated cancers conducted within the framework of the Japan-U.S. Medical Cooperation Program
  • JP23jk0210009
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Development of novel strategies for prevention, diagnosis, and treatment through comprehensive genomic analysis of rare cancers, including sarcomas and brain tumors
  • JP24ck0106877
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
N/A
N/A
Joint Research Project of the Institute Medical Science, the University of Tokyo
Investigation of the role of the gut microbiota in the serrated pathway, a novel colorectal carcinogenesis mechanism
N/A
Takeda Science Foundation
Elucidation of colorectal carcinogenesis mechanisms and development of preventive strategies based on gut microbiome dynamics toward the implementation of microbiome-driven precision medicine
N/A
Yasuda Medical Foundation
Elucidation of the mechanisms underlying colorectal carcinogenesis based on gut microbiome dynamics
N/A
The Mitsubishi Foundation
Identification of gut microbial agents involved in colorectal tumorigenesis and elucidation of their underlying mechanistic pathways
N/A
Princess Takamatsu Cancer Research Fund
Investigation of the impact of gut microorganisms on the pathogenesis of colorectal cancer
N/A
Yakult Bio-Science Foundation
Investigation of intestinal microenvironment modulation for the prevention of colorectal cancer
N/A

Related publications

TitleDOIDataset ID
Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies
https://doi.org/10.1186/s12943-024-02159-9 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.