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Research ID

hum0422-v1Release info

Latest

Research title

Multi-institutional observational study to elucidate the pathogenesis of endometrial carcinoma through integrated genomic analysis

Research overview

Aims
Endometrial cancer (EC) incidence is rising, emphasizing the need for advancements in prevention and treatment. Type I ECs have endometrioid carcinoma G1/G2 histology and depend on estrogen, while Type II ECs occur post-menopause and are estrogen-independent. Genomic analysis has identified four subtypes: ultra-mutated (POLE mutation), hypermutated (microsatellite instability), copy-number low, and copy-number high groups. However, the relationship between tumor histopathology and the genomic classification needs further clarification. To develop effective prevention and treatment, we aim to understand EC's carcinogenesis and etiology.
Methods
Whole exome sequencing, RNA sequencing
Participants/materials
89 ECs
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000894NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2026-03-31

Data provider

Principal investigator
Masahito Kawazu
Affiliation
Division of Cell Therapy, Chiba Cancer Center Research Institute

Research projects

No research projects.

Grants

NameTitleProject number
The Uehara Memorial Foundation (2022)
Genomic Alterations Driving Immune Evasion in Endometrial Cancer
N/A

Related publications

No related publications.

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Hitoshi IuchiWaseda Research Institute for Science and Engineering, Waseda UniversityJapanA comprehensive understanding of cancer through multi-omics analysis2026-09-07 – 2029-07-31
Michihiro TanikawaDepartment of obstetrics and gynecology, The University of Tokyo HospitalJapanMolecular Biological Analysis of Abnormalities Involved in the Development and Prognosis of Endometrial Cancer, Uterine Sarcoma, and Endometrial Hyperplasia2026-09-07 – 2030-03-31