Research ID
hum0413-v1Release info
This page is a past version (v1). The latest version is v2.
Latest version (v2)Research title
Comprehensive analysis on medical and omics data from patients with atopic dermatitis
Research overview
- Aims
- To contribute to medical strategies involving disease prediction, prevention, and treatment selection through collecting and analyzing human omics data. We strive to create a novel research field that integrates interdisciplinary studies, with a focus on computational science, using allergy disorders as a model.
- Methods
- RNA-seq analysis
- Participants/materials
- Atopic dermatitis 161 + 41 cases (skin tissue: 260 + 762 samples, PBMC: 461 samples)
Psoriasis: 18 cases (skin tissue: 36 samples)
41 + 10 healthy controls (skin tissue: 55 + 19 samples, PBMC: 41 samples) - URL
- N/A
Datasets
The list is the one this version published; each dataset's content is shown as it is now.
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000757 | NGS (RNA-seq) |
| Controlled-access (Type I) | 2023-07-20 |
Data provider
- Principal investigator
- Haruhiko Koseki
- Affiliation
- Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences
Research projects
| Name | URL |
|---|---|
Comprehensive analysis on medical and omics data from patients with atopic dermatitis. | N/A |
Grants
| Name | Title | Project number |
|---|---|---|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Elucidation of pathology of atopic dermatitis involving multiple organ allergy by integrating clinical and omics information |
|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Analysis on skin microbiome for establishment of precision medicine in atopic dermatitis |
|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Analysis on skin transcriptome for establishment of precision medicine in atopic dermatitis |
|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Elucidation of mechanisms underlying progression of atopic dermatitis by analysis on skin and gut microbiome |
|
Project for Development of Innovation Hub, Japan Science and Technology Agency (JST) | Hub for Predictive and Preventative Precision Medicine Driven by Big Data |
|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Innovation of microbial treatment for atopic dermatitis based on bidirectional understanding of skin microbiota and host |
|
Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED) | Interdisciplinary research on atopic dermatitis to elucidate the diversity of allergic pathophysiology and to realize sustainable data-driven precision medicine |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis. |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 | |
| Keiko Koga | Takeda Pharmaceutical Company | Japan | Exploration of therapeutic drug targets for atopic dermatitis using publicly available RNA-seq data from skin tissues and PBMCs derived from patients with atopic dermatitis (and psoriasis and healthy subjects) | 2025-08-18 – 2028-07-20 | |
| Satoshi Nakamizo | Dermatology, Kyoto University | Japan | Immunological Analysis of Immune-Mediated and Allergic Skin Diseases | 2026-04-06 – 2028-03-31 |