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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0403-v1Release info

Latest

Research title

Investigation of the utility of liquid biopsy in urologic cancer

Research overview

Aims
To prospectively identify new biomarkers by evaluating gene mutations and microRNA expression using tumor tissues and free nucleic acids collected from patients with urologic cancer.
Methods
Cell-free DNAs extracted from plasma samples were subjected to a circulating tumor DNA analysis using the AVENIO ctDNA Expanded Kit (Roche Diagnostics, Basel, Switzerland). DNA concentration was assessed using a Qubit fluorometer (Thermo Fisher Scientific, Waltham, MA, USA).
Participants/materials
16 plasma samples were collected before immune checkpoint inhibitor treatment and 9 plasma samples were collected after immune checkpoint inhibitor treatment from 16 metastatic urothelial carcinoma patients.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000751NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2023-07-01

Data provider

Principal investigator
Kazuki Hamada
Affiliation
Department of Urology, University of Tsukuba Hospital

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Application of whole blood RNA in urological cancer to understand immune cell diversity and predict therapeutic effect
  • 21K09365

Related publications

TitleDOIDataset ID
Variant allele frequency changes in TP53 predict pembrolizumab response in patients with metastatic urothelial carcinoma.
https://doi.org/10.3892/ol.2023.13975 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.