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Research ID

hum0382-v1Release info

Latest

Research title

Analysis of genetic and epigenetic abnormalities in hematopoietic diseases

Research overview

Aims
We collect tumor cells from patients with hematopoietic diseases, analyze genetic abnormalities and epigenetic abnormalities through genomic analyses, and integrate them with cell biological experiments and clinical information to understand the onset, progression, and maintenance of the disease. Specifically, what kind of genetic and epigenetic abnormalities stack up to cause hematopoietic diseases, what kind of cells are the origin of hematopoietic diseases, what kind of abnormalities lead to hematopoietic diseases, and what abnormalities influence clinical prognosis?
Methods
DNAs extracted from bone marrow mononuclear cells purified by ficoll-paque (GE HealthCare, Chicago, IL) and oral mucosa cells were used for whole-genome sequencing analysis.
Participants/materials
A patient who was initially diagnosed with myelodysplastic syndrome (MDS) and had a fusion FUS gene with ERG (FUS-ERG), and relapsed acute myeloid leukemia (AML) with FUS-ERG
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000714NGS (WGS)
  • WGS
Controlled-access (Type I)2023-01-20

Data provider

Principal investigator
Masahiro Kawahara
Affiliation
Department of Hematology, Shiga University of Medical Science

Research projects

NameURL
Analysis of genetic and epigenetic abnormalities in hematopoietic diseases
N/A

Grants

NameTitleProject number
Chugai pharmaceutical Co., Ltd
N/A
N/A
Kyowa Kirin Co., Ltd
N/A
N/A
Sanofi K.K.
N/A
N/A
MSD K.K.
N/A
N/A

Related publications

TitleDOIDataset ID
FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells
https://doi.org/10.1038/s41598-023-41230-1 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.