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NBDC Research ID:hum0362-v1

Release info

Latest

Research title

The study on genomic profiling using clinical specimens (tissue, blood, etc.) form patients with lung and thymic tumors

Research overview

Aims: This study has following four objectives 1) We identify driver mutations, classify the disease by gene profiling, and evaluate biomarkers that predict treatment efficacy and genomic changes during recurrence or metastasis. 2) We identify biomarkers that predict therapeutic efficacy and toxicity by analyzing polymorphisms of genes related to pharmacokinetics and pharmacology in non-tumor tissues and genetic mutations related to familial tumors and by performing association analysis between germline gene profiling and clinical information. 3) We compare "Clinical Liquid Sequencing" using plasma-derived free DNA with tissue biopsy ("Clinical Sequencing") to evaluate its efficacy. 4) In thymic tumors, we will examine immune cell profiling. The relationship between thymic tumors and autoimmune diseases will also be examined.

Methods: RNA-seq analysis

Targets: 98 thymoma cases (97 thymoma samples and one normal thymus sample)

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD000672	Controlled-access (Type I)	NGS (RNA-seq)	2025-04-10

Data provider

Principal investigator: Shinichi Yachida
Name: Cancer Genome Informatics, Osaka University

Research projects

Name	URL
The study on genomic profiling using clinical specimens (tissue, blood, etc.) from patients with lung and thymic tumors

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research (B)	Metagenomic analysis of familial adenomatous polyposis and its implications for understanding the pathogenesis of colorectal cancer	JP20H033620
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)	Research aimed at elucidating alterations in the intestinal microenvironment associated with colorectal cancer development in high-risk individuals, and the development of personalized preventive strategies based on these findings	JP21ck0106546
Project for Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Developmstent (AMED)	Research and development aimed at predicting the occurrence of adverse effects associated with anticancer drugs through comprehensive analysis of the gut microbiota	JP21cm0106477
Research Program on the challenges of Global Health issues, Japan Agency for Medical Research and Developmstent (AMED)	Investigation of infection-associated cancers conducted within the framework of the Japan-U.S. Medical Cooperation Program	JP20jk0210009
Project for Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Developmstent (AMED)	Development of biomarkers for early detection and susceptibility assessment of young-onset colorectal cancer through comprehensive analysis of the intestinal microenvironment	JP22ama221404
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)	Collection and analysis of whole-genome sequencing data and clinical information on treatment-resistant gastrointestinal cancers, such as esophageal cancer, with the aim of facilitating drug development and establishing a nationwide infrastructure for genome-informed medical care in Japan	JP22ck0106690
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)	Advancement of preventive, diagnostic, and therapeutic approaches through comprehensive genomic analysis of rare malignancies, including sarcomas and brain tumors	JP21ck0106693
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)	Development of novel strategies for prevention, diagnosis, and treatment through comprehensive genomic analysis of rare cancers, including sarcomas and brain tumors	JP24ck0106877
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)	Implementation of advanced cancer precision medicine through the timely and accurate return of patient-specific data, including whole-genome information, alongside the development of novel therapeutics	JP24ck0106872
the National Cancer Center Research and Development Fund		2023-A-06
Japan Health Research Promotion Bureau Research Fund		JH2022-B-01
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
Joint Research Project of the Institute Medical Science, the University of Tokyo
the Takeda Science Foundation
the Yasuda Medical Foundation
the Mitsubishi Foundation
the Princess Takamatsu Cancer Research Fund
Takara Bio Inc.

Related publications

Title	DOI	Dataset ID
Characterizing the Tumor Immune Environment in Thymic Epithelial Tumors Using T-cell Receptor Repertoire Analysis and Gene Expression Profiling	https://doi.org/10.1016/j.xjon.2025.03.008	JGAD000672

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
No data