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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0362-v1Release info

Latest

Research title

The study on genomic profiling using clinical specimens (tissue, blood, etc.) form patients with lung and thymic tumors

Research overview

Aims
This study has following four objectives
1) We identify driver mutations, classify the disease by gene profiling, and evaluate biomarkers that predict treatment efficacy and genomic changes during recurrence or metastasis.
2) We identify biomarkers that predict therapeutic efficacy and toxicity by analyzing polymorphisms of genes related to pharmacokinetics and pharmacology in non-tumor tissues and genetic mutations related to familial tumors and by performing association analysis between germline gene profiling and clinical information.
3) We compare "Clinical Liquid Sequencing" using plasma-derived free DNA with tissue biopsy ("Clinical Sequencing") to evaluate its efficacy.
4) In thymic tumors, we will examine immune cell profiling. The relationship between thymic tumors and autoimmune diseases will also be examined.
Methods
RNA-seq analysis
Participants/materials
98 thymoma cases (97 thymoma samples and one normal thymus sample)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000672NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2025-04-10

Data provider

Principal investigator
Shinichi Yachida
Affiliation
Cancer Genome Informatics, Osaka University

Research projects

NameURL
The study on genomic profiling using clinical specimens (tissue, blood, etc.) from patients with lung and thymic tumors
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Metagenomic analysis of familial adenomatous polyposis and its implications for understanding the pathogenesis of colorectal cancer
  • 20H03662
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)
Research aimed at elucidating alterations in the intestinal microenvironment associated with colorectal cancer development in high-risk individuals, and the development of personalized preventive strategies based on these findings
  • JP21ck0106546
Project for Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Developmstent (AMED)
Research and development aimed at predicting the occurrence of adverse effects associated with anticancer drugs through comprehensive analysis of the gut microbiota
  • JP21cm0106477
Research Program on the challenges of Global Health issues, Japan Agency for Medical Research and Developmstent (AMED)
Investigation of infection-associated cancers conducted within the framework of the Japan-U.S. Medical Cooperation Program
  • JP20jk0210009
Project for Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Developmstent (AMED)
Development of biomarkers for early detection and susceptibility assessment of young-onset colorectal cancer through comprehensive analysis of the intestinal microenvironment
  • JP22ama221404
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)
Collection and analysis of whole-genome sequencing data and clinical information on treatment-resistant gastrointestinal cancers, such as esophageal cancer, with the aim of facilitating drug development and establishing a nationwide infrastructure for genome-informed medical care in Japan
  • JP22ck0106690
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)
Advancement of preventive, diagnostic, and therapeutic approaches through comprehensive genomic analysis of rare malignancies, including sarcomas and brain tumors
  • JP21ck0106693
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)
Development of novel strategies for prevention, diagnosis, and treatment through comprehensive genomic analysis of rare cancers, including sarcomas and brain tumors
  • JP24ck0106877
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Developmstent (AMED)
Implementation of advanced cancer precision medicine through the timely and accurate return of patient-specific data, including whole-genome information, alongside the development of novel therapeutics
  • JP24ck0106872
the National Cancer Center Research and Development Fund
N/A
  • 2023-A-06
Japan Health Research Promotion Bureau Research Fund
N/A
  • JH2022-B-01
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
N/A
N/A
Joint Research Project of the Institute Medical Science, the University of Tokyo
N/A
N/A
the Takeda Science Foundation
N/A
N/A
the Yasuda Medical Foundation
N/A
N/A
the Mitsubishi Foundation
N/A
N/A
the Princess Takamatsu Cancer Research Fund
N/A
N/A
Takara Bio Inc.
N/A
N/A

Related publications

TitleDOIDataset ID
Characterizing the Tumor Immune Environment in Thymic Epithelial Tumors Using T-cell Receptor Repertoire Analysis and Gene Expression Profiling
https://doi.org/10.1016/j.xjon.2025.03.008 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.