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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0328-v1Release info

Latest

Research title

Frequency of germline variants in genes associated with DNA repair among adanced prostate cancer patients in Japan

Research overview

Aims
To examine the frequency of germline variants in DNA repair-associated genes among advanced Japanese prostate cancer patients
Methods
Leukocyte DNA from patients with metastatic prostate cancer at diagnosis or those who developed castration resistance during treatment were collected from multiple institutions in Japan. Multiple PCR-based target sequences of entire exon regions of the 27 genes were conducted.
Participants/materials
129 prostate cancer patients who were with metastasis at initial diagnosis or who developed castration-resistant prostate cancer during treatment and accepted data publication
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000627NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2025-04-10

Data provider

Principal investigator
Shusuke Akamatsu
Affiliation
Department of Urology, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidating the biological effect of homologous recombination repair associated gene defect in prostate cancer using plasma cell-free DNA analysis
  • 20H03814

Related publications

TitleDOIDataset ID
Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer
https://doi.org/10.1038/s41416-022-01915-2 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.