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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0321-v1Release info

Latest

Research title

Comprehensive analysis of interaction between human gene expression and environmental metagenomes

Research overview

Aims
We analyze thymic epithelial cells and intrathymic immune cells in the normal thymus and in thymoma and thymic hyperplasia tissues, which have been strongly implicated in autoimmune diseases. These analyses include conventional FACS analysis and single-cell analysis. The development, differentiation, and function of immunocompetent cells will also be analyzed from the perspective of gene expression as well as thymic regulation of immune cell responses. The results of this research will enable the identification of key molecules in thymic immune regulation as a pathogenic mechanism in various autoimmune diseases and will serve as a starting point for the development of new drug targets.
Methods
Blood cells and thymus tissues were collected and subjected to single-cell RNA sequencing using a next-generation sequencer.
Participants/materials
Peripheral blood samples from patients with myasthenia gravis, or thymus glands from the patients resected at the time of surgery were used for the analysis.
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000599NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2022-05-24

Data provider

Principal investigator
Tatsusada Okuno
Affiliation
Department of Neurology, Osaka University Graduate School of Medicine

Research projects

NameURL
Neuroimmunology Group
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Specially Promoted Research
Study of the function and development of regulatory T cells
  • 16H06295
Innovation and Clinical Research Center Project, Japan Agency for Medical Research and Development (AMED)
Study of Immunoregulatory technology targeting regulatory T cells
  • JP20gm0010005

Related publications

TitleDOIDataset ID
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
https://doi.org/10.1038/s41467-022-31951-8 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Yukinori OkadaDepartment of Statistical Genetics, Graduate School of Medicine, Osaka UniversityJapanElucidation of disease etiology by trans-layer omics analysis2024-03-05 – 2029-03-31