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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0261-v2Release info

Latest

Research title

Genome-wide association study of primary biliary cholangitis (PBC) - an additional study of 1,000 Japanese PBC patients

Research overview

Aims
Genome-wide search for susceptibility genes for primary biliary cholangitis (PBC)
Methods
Regional Heritability Mapping (RHM) and Genome-wide Association Study (GWAS)
Participants/materials
1,953 PBCs and 3,690 healthy controls
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000157RHM for 1,953 PBCs and 3,690 healthy controls
  • Genotyping by array
Unrestricted-access2021-01-08
NHA000156GWAS for 1,953 PBCs and 3,690 healthy controls
  • Genotyping by array
Unrestricted-access2021-01-08
NHA000158GWAS for 1,920 PBCs and 1,770 healthy controls
  • Genotyping by array
Unrestricted-access2021-01-19

Data provider

Principal investigator
Minoru Nakamura
Affiliation
NHO Nagasaki Medical Center & Nagasaki University Graduate School of Biomedical Sciences Division of Advanced Research, Department of Hepatology

Research projects

NameURL
PBC Consortium in Japan (PBCCJP)
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
New clinical classification and the criteria for predicting long-term outcome in primary biliary cirrhosis
  • 20590800
KAKENHI Grant-in-Aid for Scientific Research (C)
Genome-wide association study to detect disease-associated genes in Japanese patients with primary biliary cirrhosis
  • 23591006
KAKENHI Grant-in-Aid for Scientific Research (B)
Analysis of disease-pathways and molecular targets by disease-susceptibility genes in primary biliary cholangitis
  • 26293181
KAKENHI Grant-in-Aid for Early-Career Scientists
Genomic analysis of traits related to metabolic syndrome and chronic kidney disease
  • 18K14757
KAKENHI Grant-in-Aid for Young Scientists (B)
Analysis of molecular mechanisms involved in progression to jaundice and liver failure in primary biliary cholangitis
  • 15K19357
KAKENHI Grant-in-Aid for Scientific Research (C)
The role of cathepsin Z for liver failure-type progression in primary biliary cholangitis
  • 17K09449
KAKENHI Grant-in-Aid for Scientific Research (B)
GWAS-based integrated analysis of PBC to dissect the mechanism of development and progression of primary biliary cholangitis
  • 17H04169

Related publications

TitleDOIDataset ID
Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis.
https://doi.org/10.1002/hep4.1497 (opens in a new tab)