Research ID
hum0252-v3Release info
Latest
Research title
Study for molecular characteristics of adult T-cell leukemia-lymphoma and HTLV-1-associated diseases
Research overview
- Aims
- Study for molecular characteristics of adult T-cell leukemia-lymphoma and HTLV-1-associated diseases
- Methods
- Target capture sequencing, RNA-seq, single cell RNA-seq (scRNA-seq), Whole genome sequencing (WGS), scATAC-seq, ChIP-seq
- Participants/materials
- ATL 6 + 4 + 6 cases, HTLV-1 infected carrier 10 cases (infected cells and unifected cells), and 3 + 1 healthy donors
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000412 | NGS (Target Capture, RNA-seq, scRNA-seq) |
| Controlled-access (Type I) | 2021-06-30 | |
| JGAD000674 | NGS (Target Capture, WGS, scRNA-seq, scATAC-seq, ChIP-seq) |
| Controlled-access (Type I) | 2023-12-06 |
Data provider
- Principal investigator
- Makoto Yamagishi
- Affiliation
- Graduate School of Frontier Sciences, The University of Tokyo
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED) | Comprehensive study on elucidation of pathogenesis of HTLV-1 infection based on genome information and development of risk prediction algorithm |
|
Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED) | Development of risk stratification and prevention for HTLV-1-associated diseases based on multi-omics database |
|
Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED) | Integrated data science for deciphering the epigenomic code and molecular network of HTLV-1 infection and strategic drug discovery |
|
Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED) | Deep exploration for retrovirus reservoir heterogeneity and host-virus interaction by multi-phase single-cell epigenetic analysis |
|
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED) | Genome-based medicine and clinical stratification for NOTCH1-mutated malignant lymphomas |
|
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED) | A nation-wide registry and biorepository system for patients with aggressive adult T-cell leukemia-lymphoma |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Mechanisms of cooperative clonal evolution of ATL by genomic and epigenomic abnormalities |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma | ||
Mechanisms of action and resistance in histone methylation-targeted therapy |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Masao Matsuoka | Faculty of Life Sciences Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University | Japan | Retrospective observational study of characteristics, clinical course and treatment of malignant lymphoma and adult T-cell leukemia/lymphoma with genetic and pathological evaluations | 2022-05-18 – 2030-03-31 | |
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 | |
| Tomohiro Aoki | Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre | Ontario, Canada | Tumor-microenvironment ecosystem in ALCL | 2025-05-07 – 2030-02-28 |