Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0235-v1Release info

Latest

Research title

Evaluation and imaging study of the preclinical stage of Alzheimer's disease in Japan

Research overview

Aims
A study aiming to establish objective imaging and evaluation methods in preclinical Alzheimer's disease by collecting biochemical data such as psychological tests, MRI and PET images, and blood cerebrospinal fluid over time in patients with preclinical AD
Methods
We performed amyloid PET in healthy elderly and enrolled subjects with amyloid accumulation in the preclinical AD group. Subjects without amyloid accumulation were enrolled as healthy subjects. In addition, subjects who were diagnosed with MCI by psychological examination were enrolled. Those subjects underwent detailed psychological examination, MRI, FDG-PET, blood, and cerebrospinal fluid examination, and were followed up for 6 to 36 months.
Participants/materials
25 healthy elderly people without cognitive impairment
preclinical AD (ICD10: F00): 3 cases
early MCI (ICD10: F06.7): 7 cases
late MCI (ICD10: F06.7): 5 cases
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000378Brain MRI, PET (FDG, Amyloid PIB/florbetapir/flutemetamol, Tau flortaucipir), clinical/psychometric tests, and biochemical assays from the AMED-Pre study of preclinical Alzheimer's disease.
  • MRI imaging
Controlled-access (Type I)2021-04-06

Data provider

Principal investigator
Hiroyuki Shimada
Affiliation
Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine

Research projects

NameURL
AMED Preclinical AD study group (Clinical Sites, Citation Information [see 'Other related information'])

Grants

NameTitleProject number
Research and Development Grants for Dementia, Japan Agency for Medical Research and Development (AMED)
Evaluation and imaging study of the preclinical stage of Alzheimer's disease in Japan
  • JP19dk0207020

Related publications

TitleDOIDataset ID
A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer's Disease
https://doi.org/10.14283/jpad.2021.37 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Yasuhiko IKARIMolecular Imaging Center for Clinical Research and Innovation, Kobe City Medical Center General HospitalJapanDevelopment of imaging biomarkers on clinical study image database for Alzheimers disease.2021-06-16 – 2024-05-01