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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0232-v1Release info

Latest

Research title

Evaluation of metastasis and recurrence by monitoring circulating tumor DNA of gastric cancer

Research overview

Aims
To evaluate a clinical validity of circulating tumor DNA (ctDNA) of tumor-unique mutations identified in gastric cancer tissues, as a personalized tumor marker.
Methods
Pre- and post-operational plasma, primary tumor tissues, and peripheral blood mononuclear cells (PBMCs) were collected from 10 enrolled gastric cancer patients. The primary tumor specimens were taken from three regions immediately after the operation, and the cellularity of all specimens was microscopically confirmed to be >30%. DNAs are extracted from 30 primary tumor specimens and 10 PBMCs, and target capture sequencing for 151 genes that have been implicated in a wide range of cancers was performed.
Participants/materials
Gastric cancer patients with preoperative diagnosis of Stage IB or higher. An individual written consent was obtained from each participant.
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000325NGS (Target Capture)
  • Targeted DNA sequencing
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Satsoshi Nishizuka
Affiliation
Division of Biomedical Research and Development, Iwate Medical University Institute for Biomedical Sciences

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Establishment of selection process of molecular targeting drugs in response to biological heterogeneity in drug-resistant cancer cells
  • 16H01578
KAKENHI Fund for the Promotion of Joint International Research (Fostering Joint International Research)
Identification of compounds that potentially lead to the cancer relapse suppression on the basis of drug-resistant cancer subpopulation model (original)
  • 15KK0317
KAKENHI Grant-in-Aid for Scientific Research (C)
Circumvent practical issues for introducing ctDNA into daily practice
  • 19K09224
KAKENHI Grant-in-Aid for Scientific Research (C)
Effect of immune response to Helicobacter pylori on adjuvant chemotherapy for gastric cancer
  • 19K09130
KAKENHI Grant-in-Aid for Scientific Research (C)
Development of monitoring system for esophageal cancer by quantifying circulating tumor DNA
  • 17K10605

Related publications

TitleDOIDataset ID
Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA
https://doi.org/10.1371/journal.pone.0239966 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.