Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0144-v1Release info

Latest

Research title

Comprehensive analysis of genetic alterations in hematological malignancies (pediatric B-cell precursor acute lymphoblastic leukemia in Down syndrome)

Research overview

Aims: To explore genetic alteratoins in pediatric B-cell precursor acute lymphoblastic leukemia in Down syndrome
Methods: SNP array, whole transcriptome sequencing, and DNA methylation array were performed in cases of pediatric B-cell precursor acute lymphoblastic leukemia in Down syndrome
Participants/materials: 43 pediatric B-cell precursor acute lymphoblastic leukemia cases in Down syndrome
URL: N/A

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000221	NGS (RNA-seq) Methylation array SNP array	RNA-seq Genotyping by array メチル化アレイ	Controlled-access (Type I)	2020-09-28

Data provider

Principal investigator: Junko Takita
Affiliation: Department of Pediatrics, Graduate School of Medicine, The University of Tokyo

Research projects

Name	URL
Comprehensive analysis of genetic aberrations in hematologic malignancies	N/A

Grants

Name	Title	Project number
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)	Development for novel therapeutic stratagies of intractable cancers in children and adolescent and young adult using molecular profilings	JP16cm0106509
KAKENHI Grant-in-Aid for Scientific Research (B)	Development for novel therapeutic stratagies of intractable pediatric cancers based on the multi-omics analysis	17H04224

Related publications

Title	DOI	Dataset ID
Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome	https://doi.org/10.1111/cas.14160 (opens in a new tab)	JGAD000221

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Jinyan Huang	Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang University	China	Comprehensive analysis of alternative splicing in malignant tumors	2022-03-15 – 2024-01-01	JGAD000221
Ching Lau	Pediatric Oncology, The Jackson Lab for Genomic Medicine	Connecticut, United States	AML in Down's Syndrome	2022-08-18 – 2028-01-13	JGAD000221
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000221
Sebastien Malinge	Translational Genomics in Leukaemia, The Kids Research Institute Australia		Identifying the genetic alterations contributing to leukaemia development in children.	2026-01-02 – 2027-12-31	JGAD000221