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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0117-v1Release info

Latest

Research title

Epigenetics analysis of neurodegenerative diseases

Research overview

Aims
Detecting Neuron-specifc methylation changes in Alzheimer's disease brain
Methods
Illumina Infinium® Human Methylation 450K BeadChip
Participants/materials
30 Alzheimer's diseasepatients and 30 healthy controls
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000136Methylation array
  • メチル化アレイ
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Atsushi Iwata
Affiliation
The University of Tokyo Hospital

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
A novel neuro-epigenetic approach to the pathogenic mechanism of the neurodegenerative dementia diseases
  • 16H05319
KAKENHI Grant-in-Aid for Young Scientists (B)
Analysis of DNA damage mechanism in the novel cellular and mouse model of Alzheimer's disease
  • 17K16113
Strategic Research Program for Brain Sciences, Japan Agency for Medical Research and Development (AMED)
Development of a new disease-modifying therapy and early diagnostic method of Alzheimer's disease based on a cause of amyloid deposition observed in sporadic type
  • JP16dm0107069

Related publications

TitleDOIDataset ID
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
https://doi.org/10.1073/pnas.1707151114 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.