Research ID
hum0085-v2Release info
Latest
Research title
Molecular biological research affecting on long-term treatment to malignant tumors derived from the chest or abdomen / Genomic analysis of environment-associated tumors
Research overview
- Aims
- Malignant mesotheliomas (MMs) are highly aggressive adult malignancies and exposure to asbestos is the major factor involved in MM pathogenesis. It is desirable for a better understanding of the molecular pathogenesis of MM will lead to more specific and effective targeted therapies. It is reported that germline mutation in a specific gene associates familial MMs. New candidate markers to determine a subject's predisposition to MM and for early detection need to be identified. Analysis of genomic DNA from MM tumors and reference peripheral blood cells from Japan, USA, and Turkey's patients are ongoing to find the common genomic characters beyond race.
- Methods
- Array CGH for chromosome 3p21, Whole Genome Sequencing (NGS), Target Capture Sequencing (NGS) and Whole Exome Sequencing (NGS)
- Participants/materials
- Genomic DNA from MM tumors and reference peripheral blood cells
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000116 | Array CGH NGS (WGS) NGS (Target Capture) |
| Controlled-access (Type I) | 2020-09-28 |
Data provider
- Principal investigator
- Masaki Ohmuraya
- Affiliation
- Department of Genetics, Hyogo College of Medicine
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
KAKENHI Grant-in-Aid for Scientific Research (C) | Deletion of the 3p region in malignant mesothelioma cells derived from Japanese patients |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Basic research about the medical treatment based on the genomic instability of malignant mesothelioma from Japanese patients |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Analysis of genome structural abnormalities of 3p21 in environment-associated cancers |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Search about germline genetic predisposition to malignant mesothelioma |
|
Grant-in-Aid for Researchers from Hyogo College of Medicine | International collaborative research to search for the predisposition genes to malignant mesothelioma -the predisposition genes which are not confined to a particular race and asbestos exposure condition |
|
Grant-in-Aid for Researchers from Hyogo College of Medicine | Genetic variants associated with increased risk of malignant mesothelioma in Japanese. |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma | ||
A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Kouya Shiraishi | Division of Genome Biology, National Cancer Research Institute | Japan | Elucidation of immune-system networks between host and tumor based on genomic analysis | 2019-08-05 – 2029-03-31 | |
| Masanori Arita | Bioinformation and DDBJ Center, National Institute of Genetics | Japan | Provision of processed JGA data analyzed by DDBJ Center and NBDC | 2021-10-07 – 2030-03-31 |