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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0048-v1Release info

Latest

Research title

Whole exome sequencing on ampullary carcinomas

Research overview

Aims
The genomic biology of ampullary carcinomas is currently poorly defined, we have conducted an in-depth analysis of the genomic abnormalities of these carcinomas through an international multicenter collaboration to establish a potential basis for treatments of this disease.
Methods
Whole exome sequencing was performed on the Illumina HiSeq 2000/2500 platforms in a discovery set of 60 ampullary carcinomas.
Participants/materials
We investigated a large cohort of clinically and pathologically well-characterized patients with ampullary cancer that included 28 Japanese patients and 32 American patients.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
DRA004251NGS (Exome)
  • WES
Unrestricted-access2016-02-05

Data provider

Principal investigator
Shinichi Yachida
Affiliation
Laboratory of Clinical Genomics, National Cancer Center Research Institute / Department of Cancer Genome Informatics, Graduate School of Medicine/Faculty of Medicine, Osaka University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
Molecular pathological analysis and prediction of clinical course of a rare tumor by systematic approach to biology
  • 25134719

Related publications

TitleDOIDataset ID
Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma
https://doi.org/10.1016/j.ccell.2015.12.012 (opens in a new tab)