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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0034-v1Release info

Latest

Research title

Identification of novel therapeutic targets of small cell lung cancer by comprehensive genomic analyses

Research overview

Aims
Identifying new therapeutic targets of small cell lung cancer (SCLC), genome-wide mutation analysis has been performed.
Methods
Genomic DNA was extracted from formalin-fixed or methanol-fixed tissue samples. 71 Mb of DNA fragments containing whole coding exons were concentrated using SureSelect Human All Exon V4+UTRs Kit (Agilent Technologies) followed by 100-bp paired end sequencing by HiSeq 2000 (Illumina).
Participants/materials
51 of 1042 cases of pathologically diagnosed small seen lung cancer that were registered to National Cancer Hospital East Lung Cancer Database in 1992-2012, and which surgically resected or biopsy samples were suitable for DNA extraction for further analyses.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000037Exome (NGS)
  • WES
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Koichi Goto
Affiliation
Department of Thoracic Oncology, National Cancer Center Hospital East

Research projects

NameURL
Development of molecular targeted therapy for small cell lung cancer by comprehensive genome analysis
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Exploring therapeutic targets and investigating molecular carcinogenesis of small cell lung cancer by comprehensive genome analysis
  • 24300346
KAKENHI Grant-in-Aid for Young Scientists (B)
Development of molecular targeted therapy for large cell neuroendocrine carcinoma by targeting genome sequencing
  • 26870876
National Cancer Center Research and Development Fund
Development of the biostatistics and bioinformatics platforms for cancer research
  • 23-A-8
National Cancer Center Research and Development Fund
Development of the platforms for early phase clinical trials
  • 23-A-15
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)
Development of molecular targeted therapy for small cell lung cancer by comprehensive genome analysis
  • JP15cm0106063

Related publications

TitleDOIDataset ID
Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.
https://doi.org/10.1097/JTO.0000000000000250 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Anton BernsDivision of Molecular Genetics, The Netherlands Cancer InstituteNetherlandsIntegrative analysis of small cell lung cancer2016-03-30 – 2017-09-12
Hirofumi NakaokaDepartment of Cancer Genome Research, Sasaki InstituteJapanGenetic analysis of lung cancer2022-08-17 – 2026-07-23