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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0033-v1Release info

Latest

Research title

Functional analysis of two types of exosome in human whole saliva

Research overview

Aims
Human whole saliva (WS) contains two types of exosomes (exosome I and exosome II) that are small membrane vesicle (30-100 nm in diameter). To clarify the host defense functions of exosomes, we investigated long RNA components (protein-coding RNAs and long non-coding RNAs) of exosome I, exosome II, and WS by next generation sequencing.
Methods
Human whole saliva was collected by discharge. Long RNA components (protein-coding RNA and long non-coding RNA) of exosome I, exosome II, and WS were analyzed by next generation sequencing.
Participants/materials
Human whole saliva was collected from one Japanese healthy female volunteer with written informed consent.
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
DRA003516NGS (RNA-seq)
  • RNA-seq
Unrestricted-access2015-04-27

Data provider

Principal investigator
Ryohei Yanoshita
Affiliation
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Teikyo Heisei University

Research projects

NameURL
Membrane Function Research Unit
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Molecular mechanisms and regulations of immune activation cascades by exosomes expressing aminopeptidases.
  • 25460172
Japan Science and Technology Agency (JST) Industry-academia Joint Seeds Innovation Project
Development of a nanocarrier derived from biogenic substances for application to drug development.
N/A

Related publications

TitleDOIDataset ID
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
https://doi.org/10.1248/bpb.b12-00607 (opens in a new tab)