NBDC Research ID: hum0501.v1
SUMMARY
Aims: The number of basal divergences, admixture, and the degrees of isolation among Indigenous North Eurasian and Native South American populations remain debated, with most insights derived from genome-wide genotyping data. This study aims to improve our understanding of the ancient dynamics and shaping of the contemporary populations of North Eurasia and the Americas. Using large-scale whole-genome sequencing of 1,537 individuals across 139 ethnic groups from these regions, we identify population structures, clarify the prehistoric migrations and the role of past environments in the diversification of human populations.
Methods: Whole genome sequencing
Participants/Materials: 1,323 healthy individuals
URL: https://www.genomeasia100k.org/
| Data Set ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000781 | NGS (WGS) | Controlled-access (Type I) | 2025/05/15 |
*Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
MOLECULAR DATA
| Participants/Materials |
1,323 healthy individuals 313 from ADRC (Asian DNA Repository Consortium) 486 from RIMG (Research Institute of Medical Genetics SB RAMS in Russia) 524 from GenomeAsia 100K Project (GenomeAsia 100K Consortium, 2019, Nature) |
| Targets | WGS |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq X] |
| Library Source | gDNA extracted from saliva or peripheral blood |
| Cell Lines | - |
| Library Construction (kit name) | TruSeq DNA Nano |
| Fragmentation Methods | Ultrasonic fragmentation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 150 bp x 2 |
| QC |
Variants with VQSLOD <0 were excluded. removed multi-allelic SNPs and indels, remaining only biallelic SNPs. |
| Deduplication | SAMBLASTER |
| Calibration for re-alignment and base quality | - |
| Mapping Methods | BWA-MEM v0.7.13 |
| Mapping Quality | MAPQ = ~60 |
| Reference Genome Sequence | GRCh37 |
| Coverage (Depth) | >20X |
| Detecting Methods for Variation | GATK v3.5 |
| SNP Numbers (after QC) | 52,589,813 |
| INDEL Numbers (after QC) | - |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000923 |
| Total Data Volume | 310.8 GB (vcf, tabix) |
| Comments (Policies) | NBDC policy and Company User Limit |
DATA PROVIDER
Principal Investigator: Hie Lim Kim
Affiliation: Asian School of the Environment, Nanyang Technological University
Project / Group Name: -
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| GenomeAsia 100K consortium |
PUBLICATIONS
| Title | DOI | Data Set ID | |
|---|---|---|---|
| 1 | From North Asia to South America: Tracing the longest human migration through genomic sequencing | doi: 10.1126/science.adk5081 | JGAD000923 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
