NBDC Research ID: hum0499.v1
SUMMARY
Aims: Malignant bone and soft tissue tumors are cancerous diseases that occur in bone and soft tissue, but they only account for around 1% of all cancers. Furthermore, malignant bone and soft tissue tumors are classified in a very complex way based on pathological histology, and there are over 150 types of tissue, including both benign and malignant tumors. As a result, diagnosis is difficult, and there are cases where appropriate treatment cannot be provided. There are many cases of bone and soft tissue tumors with a poor prognosis due to the rarity of the disease, histological diversity, and intractability. The aim of this study is to develop biomarkers to assist in diagnosis and to elucidate the pathology with the aim of developing new treatment methods.
Methods: Sanger sequencing
Participants/Materials: Sarcoma 6 cases
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000787 | Sanger sequencing | Controlled-access (Type I) | 2025/04/25 |
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MOLECULAR DATA
| Participants/Materials | Sarcoma (ICD10: D48.1): 6 cases, 10 plasma samples |
| Targets | Sanger sequencing |
| Target Loci for Capture Methods | EWSR1-FLI1, FUS-DDIT3 |
| Platform | Applied Biosystems [3730xl DNA Analyzer] |
| Library Source | cfRNA from plasma samples |
| Cell Lines | - |
| Library Construction (kit name) | BigDye Terminator v3.1 Cycle Sequencing Kit |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000929 |
| Total Data Volume | 2.2 MB (ab1) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Nobuhiko Hasegawa
Affiliation: Department of Orthopaedics, Faculty of Medicine, Juntendo University
Project / Group Name: Development of molecular markers for bone and soft tissue tumors
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Early-Career Scientists | Development of molecular markers using blood samples in bone and soft tissue tumors | 22K16721 |
| KAKENHI Fund for the Promotion of Joint International Research (Fostering Joint International Research) | Exploration of therapeutic targets and development of biomarkers focusing on fusion genes in bone and soft tissue tumors | 23KK0310 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | |||
| 2 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
