NBDC Research ID: hum0437.v1
SUMMARY
Aims: Malignant brain tumors are refractory to treatment and have a poor prognosis. In recent years, molecular genetic analyses of malignant brain tumors have rapidly progressed, and several genetic abnormalities have been found to be predictive of prognosis and response to treatments. In this study, we will comprehensively examine genetic abnormalities in malignant brain tumors and compare them with clinicopathological information to identify genes that are involved in tumor development or malignant transformation, or that are useful as biomarkers for diagnosis and early detection of recurrence, and that may be targets for therapies, and apply these genes to ancillary research and allocation factors in clinical trials.
Methods: RNA-seq analysis
Participants/Materials: A total of 124 fresh-frozen tumor tissues from 124 patients with glioma
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000671 | NGS (RNA-seq) | Controlled-access (Type I) | 2024/03/05 |
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MOLECULAR DATA
| Participants/Materials |
glioma (ICD10: C71): 124 cases 124 fresh-frozen tumor tissues |
| Targets | RNA-seq |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 6000] |
| Library Source | RNAs extracted from fresh frozen tumor tissues |
| Cell Lines | - |
| Library Construction (kit name) | Twist Library Preparation EF Kit |
| Fragmentation Methods | Enzymatic fragmentation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 150 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000801 |
| Total Data Volume | 428.1 GB (fastq) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Shinji Kohsaka
Affiliation: Division of Cellular Signaling, National Cancer Center Research Institute
Project / Group Name: -
URL: https://www.ncc.go.jp/en/ri/division/genetics/index.html
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Grant-in-Aid for Rare Cancer Research, National Cancer Center | Exploration of Novel Therapeutic Targets in Malignant Brain Tumors of the AYA and Late Middle Age | 1-7 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma | doi: 10.1007/s11060-024-04563-z | JGAD000801 |
| 2 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
