NBDC Research ID: hum0332.v1

 

SUMMARY

Aims: To detect predictive biomarkers for genitourinary cancer treatment.

Methods: Whole exome sequencing analysis

Participants/Materials: Genomic DNAs extracted from tumor tissues and leukocytes that were obtained from one castration-resistant prostate cancer (CRPC) patient.

 

Dataset IDType of DataCriteriaRelease Date
JGAS000510 NGS (Exome) Controlled-access (Type I) 2022/05/30

*Release Note

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MOLECULAR DATA

JGAS000510
Participants/Materials

CRPC (ICD10: C61):  1 case

     tumor tissues, leukocytes: 1 sample each
Targets Exome
Target Loci for Capture Methods -
Platform Illumina [Nova Seq 6000]
Library Source DNAs extracted from tumor tissues and leukocytes
Cell Lines -
Library Construction (kit name) SureSelectXT Library Prep Kit
Fragmentation Methods Ultrasonic fragmentation (Covaris)
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 150 bp
Japanese Genotype-phenotype Archive Dataset ID JGAD000628
Total Data Volume 13.4 GB (fastq, tab)
Comments (Policies) NBDC policy

 

DATA PROVIDER

Principal Investigator: Shusuke Akamatsu

Affiliation: Kyoto University Graduate School of Medicine Department of Urology

Project / Group Name: -

Funds / Grants (Research Project Number):

NameTitleProject Number
KAKENHI Grant-in-Aid for Scientific Research (B) Understanding the biological mechanisms of defective DNA damage repair in prostate cancer using cell-free DNA analysis 20H03814

 PUBLICATIONS

TitleDOIDataset ID
1 A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months doi: 10.1101/mcs.a006194 JGAD000628
2

 

USRES (Controlled-Access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use