NBDC Research ID: hum0293.v1
SUMMARY
Aims: Exploration of genetic factors that contribute to molecular pathogenesis and therapeutic sensitivity of hematopoietic malignancies
Methods: 1. Genomic DNA was extracted from peripheral blood mononuclear cells of primary adult T-cell leukemia/lymphoma (ATL) patients. Library construction and whole-genome sequencing analysis were performed.
2. After genetic modifications in the ATL Cell line (TL-om1 cell), genomic DNA was extracted from the cells. Library construction and whole-genome sequencing analysis were performed.
Participants/Materials: ATL patients and ATL cell line
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000320 | NGS (Target Capture) | Controlled-access (Type I) | 2022/07/25 |
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MOLECULAR DATA
| Participants/Materials |
ATL (ICD10: C91.5): 7 cases ATL cell line (TL-om1 cell): 1 sample (12 genetic modifications) |
| Targets | WGS |
| Target Loci for Capture Methods | - |
| Platform |
Illumina [HiSeqX10] BGI [BGISEQ-500] |
| Library Source | DNAs extracted from peripheral blood mononuclear cells of primary ATL patients or genetic modified ATL cell line (TL-om1 cell) |
| Cell Lines | - |
| Library Construction (kit name) | BGI's standard protocol |
| Fragmentation Methods | BGI's standard protocol |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 150 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000431 |
| Total Data Volume | 1.1 TB（fastq） |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Takaomi Sanda
Affiliation: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences / Cancer Science Institute of Singapore, National University of Singapore
Project / Group Name: -
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research) | Understanding of molecular pathogenesis and development of therapeutics by enhancer profiling | 18K19960 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | |||
| 2 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
