NBDC Research ID: hum0240.v1



Aims: To explore molecular targets of primary central nervous system lymphoma (PCNSL)

Methods: Target amplicon sequencing analysis was performed using Target Capture technology (NGS) on Cancer Panel

Participants/Materials: PCNSL patients


Dataset IDType of DataCriteriaRelease Date
JGAS000258 NGS (Target Capture) Controlled-access (Type I) 2020/10/30

*Release Note

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Participants/Materials PCNSL (ICD10: C859): 28 cases
Targets Target Capture
Target Loci for Capture Methods 409 genes (Ion Ampliseq Comprehensive Cancer Panel)
Platform Thermo Fisher Scientific [Ion Torrent]
Library Source DNAs extracted from primary tumor tissues and peripheral blood cells
Cell Lines -
Library Construction (kit name) Ion AmpliSeq™ Library Kit 2.0
Fragmentation Methods FuPa Reagent (Thermo Fisher Scientific)
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 100 bp
Japanese Genotype-phenotype Archive Dataset ID JGAD000361
Total Data Volume 26 GB(fastq)
Comments (Policies) NBDC policy



Principal Investigator: Ryuya Yamanaka

Affiliation: Laboratory of Molecular Targeted Therapy for Cancer, Kyoto Prefectural University of Medicine

Project / Group Name: Genome-wide analysis in patients with primary central nervous system lymphomas.

Funds / Grants (Research Project Number):

NameTitleProject Number
KAKENHI Grant-in-Aid for Scientific Research (B) Exploring molecular targets for primary central nervous system lymphomas based on genome-wide analysis. 16H05441
KAKENHI Grant-in-Aid for Scientific Research (B) Development of molecular targeted therapy for primary central nervous system lymphomas. 24390347



TitleDOIDataset ID
1 Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma doi: 10.18632/oncotarget.25463 JGAD000361


USRES (Controlled-access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use