NBDC Research ID: hum0199.v1
SUMMARY
Aims: We analyzed gene expression changes in the development, progression and aquirement of therapeutic resistance of prostate cancer.
Methods: We extract total RNAs and performed RNA-sequence analysis.
Participants/Materials: Prostate tissues including benign and tumor tissues obtained by surgery and tumor tissues of metastasis or relapsed
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000198 | NGS (RNA-seq) | Controlled-access (Type I) | 2020/06/29 |
*Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
MOLECULAR DATA
| Participants/Materials |
Prostate cancer (ICD10: C61): 25 cases primary tumor and paired non-tumor tissues: 6 cases primary tumor tissues: 13 cases metastasis tumor tissues: 4 cases metastasis and relapsed tumors tissues: 2 cases |
| Targets | RNA-seq |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 2500] |
| Library Source | total RNAs extracted from surgicallly resected tumor and non-tumor tissues |
| Cell Lines | - |
| Library Construction (kit name) | TrueSeq RNA library preparation |
| Fragmentation Methods | included in the above library construction kit |
| Spot Type | Single-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 50 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000283 |
| Total Data Volume | 48 GB (bam [ref: hg19]) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Tetsuya Fujimura
Affiliation: Department of Urology, Graduate Scool of Medicine, University of Tokyo
Project / Group Name: Identification of therapeutic target molecules for urologic cancers by using next generation sequencer
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (B) | Investigation of epigenetic mechanisms driving resistance to hormone-therapy and their clinical implications in prostate cancer | 17H04334 |
| KAKENHI Grant-in-Aid for Scientific Research (C) | Precision medicine for metastatic prostate cancer via estrogen and androgen blockade | 18K09128 |
| KAKENHI Grant-in-Aid for Scientific Research (C) | Personalized medicine for advanced prostate cancer | 15K10576 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Identification of long non-coding RNAs in advanced prostate cancer associated with androgen receptor splicing factors | doi: 10.1038/s42003-020-01120-y | JGAD000283 |
| 2 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
| Michiaki Hamada | Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | JGAD000283 | 2022/12/26-2025/03/31 |
