NBDC Research ID: hum0156.v1
SUMMARY
Aims: To clarify mechanisms of resistance to chemoradiotherapy for esophageal cancer
Methods: DNA was extracted from peripheral blood cells and tumor tissues obtained by endoscopyc biopsy or surgery. Then whole exome sequencing was performed.
Participants/Materials: Esophageal cancers treated with chemoradioherapy
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000227 | NGS (Exome) | Controlled-access (Type I) | 2021/07/30 |
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MOLECULAR DATA
| Participants/Materials |
Esophageal cancer: 33 cases tumor tissues: 52 samples peripheral blood: 33 samples |
| Targets | Exome |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 2500] |
| Library Source | DNAs extracted from tumor tissues or peripheral blood from esophageal cancer patients |
| Cell Lines | - |
| Library Construction (kit name) | Agilent SureSelect XT Human All Exon V5+Reg |
| Fragmentation Methods | Ultrasonic fragmentation (Covaris) |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 100 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000319 |
| Total Data Volume | 1 TB (fastq) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Koshi Mimori
Affiliation: Department of Surgery, Kyushu University Beppu Hospital
Project / Group Name: -
URL: https://www.beppu.kyushu-u.ac.jp/gekareview/en/
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (C) | Clonal evolution of esophageal cancer genome and immune response that produce chemoradiotherapy resistance | 19K08123 |
| KAKENHI Grant-in-Aid for Scientific Research (C) | Analysis of genomic and epigenomic intratumoral heterogeneity reveals mechanisms of resistance to chemoradiotherapy in esophageal cancer | 16K10397 |
| KAKENHI Grant-in-Aid for Young Scientists (B) | Next-generation sequencing approach detect chemoradiotherapy response in esophageal cancer | 26861003 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy | doi: 10.1158/0008-5472.CAN-21-0653 | JGAD000319 |
| 2 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|
