NBDC Research ID: hum0140.v1
SUMMARY
Aims: Establishment of novel prediction method of preoperative chemoradiothearpeutic effect based on the molecular profiling in rectal cancer patients
Methods: Exome analysis by using Illumina Hiseq 2000
Participants/Materials: 74 rectal cancer patients treated with preoperative chemoraidotherapy
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000158 | NGS (Exome) | Controlled-access (Type I) | 2019/11/19 |
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MOLECULAR DATA
| Participants/Materials | 74 rectal cancer (ICD10: C20 [NG80]) treated with preoperative chemoraidotherapy |
| Targets | Exome |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 2000] |
| Library Source | DNAs extracted from non-tumor tissues (or peripheral blood cells as normal tissues) and the primary tumor tissues |
| Cell Lines | - |
| Library Construction (kit name) |
SureSelect Custom(v5n) or SureSelect Custom(v5) - v5n: SureSelect Human All Exon V5 + lincRNA + Virus - v5: SureSelect Human All Exon V5 + lincRNA |
| Fragmentation Methods | Ultrasonic fragmentation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 200 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000236 |
| Total Data Volume | 2 TB (fastq) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Takashi Akiyoshi
Affiliation: The Cancer Institute Hospital of JFCR
Project / Group Name: -
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (C) | Genomic Profile of Responders to Preoperative Chemoradiotherapy for Advanced Rectal Cancer | 15K10156 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Immunogenomic profiles associated with response to neoadjuvant chemoradiotherapy in patients with rectal cancer. | doi: 10.1002/bjs.11179 | JGAD000236 |
| 2 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
| Kouya Shiraishi | Division of Genome Biology, National Cancer Research Institute | Elucidation of immune-system networks between host and tumor based on genomic analysis | JGAD000236 | 2020/09/18-2023/03/31 |
