Dataset ID

NHA000203

Name: NHA000203: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Published: 2025-10-27

Type of data: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Access criteria: Unrestricted-access
Total data volume: 1.2 TB
File formats: TXT
XLSX
Research: hum0197
Date published: 2025-10-27
Date modified: 2025-10-27
Secondary ID: hum0197.v26.374-traits.v1

Unrestricted-access files linked to this dataset

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File	Label	Size	Copy URL
BBJ1.metabolome.Creatinine.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.Creatinine.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.Creatinine.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.Creatinine.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.Creatinine.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.Creatinine.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.Creatinine.Physical_activity.txt.gz		53.8 MB
BBJ1.metabolome.Creatinine.Sex.txt.gz		53.6 MB
BBJ1.metabolome.DHA.Age.txt.gz		52.9 MB
BBJ1.metabolome.DHA.Combined.txt.gz		32.3 MB
BBJ1.metabolome.DHA.Current_smoking.txt.gz		53.8 MB
BBJ1.metabolome.DHA.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.DHA.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.DHA.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.DHA.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.DHA.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.DHA.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.DHA.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.DHA.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.DHA.Sex.txt.gz		53.6 MB
BBJ1.metabolome.DHA_pct.Age.txt.gz		53.1 MB
BBJ1.metabolome.DHA_pct.Combined.txt.gz		32.3 MB
BBJ1.metabolome.DHA_pct.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.DHA_pct.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.DHA_pct.European_cuisine.txt.gz		53.4 MB
BBJ1.metabolome.DHA_pct.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.DHA_pct.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.DHA_pct.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.DHA_pct.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.DHA_pct.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.DHA_pct.Physical_activity.txt.gz		53.6 MB
BBJ1.metabolome.DHA_pct.Sex.txt.gz		53.6 MB
BBJ1.metabolome.Gln.Age.txt.gz		53.2 MB
BBJ1.metabolome.Gln.Combined.txt.gz		32.3 MB
BBJ1.metabolome.Gln.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.Gln.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.Gln.European_cuisine.txt.gz		53.4 MB
BBJ1.metabolome.Gln.Ever_drinking.txt.gz		53.8 MB
BBJ1.metabolome.Gln.Ever_smoking.txt.gz		53.8 MB
BBJ1.metabolome.Gln.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.Gln.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.Gln.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.Gln.Physical_activity.txt.gz		53.7 MB
BBJ1.metabolome.Gln.Sex.txt.gz		53.6 MB
BBJ1.metabolome.Glucose.Age.txt.gz		53.7 MB
BBJ1.metabolome.Glucose.Combined.txt.gz		32.2 MB
BBJ1.metabolome.Glucose.Current_smoking.txt.gz		53.6 MB
BBJ1.metabolome.Glucose.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.Glucose.European_cuisine.txt.gz		53.3 MB
BBJ1.metabolome.Glucose.Ever_drinking.txt.gz		53.5 MB
BBJ1.metabolome.Glucose.Ever_smoking.txt.gz		53.5 MB
BBJ1.metabolome.Glucose.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.Glucose.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.Glucose.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.Glucose.Physical_activity.txt.gz		53.3 MB
BBJ1.metabolome.Glucose.Sex.txt.gz		53.3 MB
BBJ1.metabolome.Gly.Age.txt.gz		52.8 MB
BBJ1.metabolome.Gly.Combined.txt.gz		32.3 MB
BBJ1.metabolome.Gly.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.Gly.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.Gly.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.Gly.Ever_drinking.txt.gz		53.8 MB
BBJ1.metabolome.Gly.Ever_smoking.txt.gz		53.8 MB
BBJ1.metabolome.Gly.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.Gly.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.Gly.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.Gly.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.Gly.Sex.txt.gz		53.5 MB
BBJ1.metabolome.GlycA.Age.txt.gz		53.2 MB
BBJ1.metabolome.GlycA.Combined.txt.gz		32.3 MB
BBJ1.metabolome.GlycA.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.GlycA.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.GlycA.European_cuisine.txt.gz		53.5 MB
BBJ1.metabolome.GlycA.Ever_drinking.txt.gz		53.8 MB
BBJ1.metabolome.GlycA.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.GlycA.Japanese_cuisine_Washoku.txt.gz		53.9 MB
BBJ1.metabolome.GlycA.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.GlycA.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.GlycA.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.GlycA.Sex.txt.gz		53.6 MB
BBJ1.metabolome.HDL_C.Age.txt.gz		53.2 MB
BBJ1.metabolome.HDL_C.Combined.txt.gz		32.3 MB
BBJ1.metabolome.HDL_C.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.HDL_C.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.HDL_C.European_cuisine.txt.gz		53.4 MB
BBJ1.metabolome.HDL_C.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.HDL_C.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.HDL_C.Japanese_cuisine_Washoku.txt.gz		53.8 MB
BBJ1.metabolome.HDL_C.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.HDL_C.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.HDL_C.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.HDL_C.Sex.txt.gz		53.6 MB
BBJ1.metabolome.HDL_CE.Age.txt.gz		53.2 MB
BBJ1.metabolome.HDL_CE.Combined.txt.gz		32.3 MB
BBJ1.metabolome.HDL_CE.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.HDL_CE.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.HDL_CE.European_cuisine.txt.gz		53.4 MB
BBJ1.metabolome.HDL_CE.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.HDL_CE.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.HDL_CE.Japanese_cuisine_Washoku.txt.gz		53.8 MB

701–800 / 8930

Analysis method

genome wide SNPs

Materials and participants: BioBank Japan (n=166,757), UK Biobank (n=273,453)
(ICD 10: E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J30.2)
no. Phenotypes: 374; Health status
Mixed
Subject count
440,210 (Individual)
Cohort
BioBank Japan, UK Biobank
Population
British, Japanese
Disease: Type 2 diabetes mellitus
Sample description: DNAs extracted from peripheral blood cells; Tissue
Peripheral blood
Tumor / normal
Normal
Sample provider: N/A
Experimental method: Genotyping by array
Target: N/A
Reagent kit: HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform: Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
QC and filtering: Clinical Phenotypes: imputation quality > 0.7, minor allele frequency (MAF) > 0.01, autosomal variants
Metabolome: further restricted to (i) genotyped variants, (ii) HapMap3 variants, and (iii) the variants with P_G×E < 1.0×10^-7 in BBJ or UKBB for at least one of the clinical traits
Imputation: BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
Analysis method: GEM
Variant count: BBJ: 7,444,735 (Clinical traits)
1,009,566 (Metabolome)
UK Biobank: 9,813,264 (Clinical traits)
1,478,430 (Metabolome)
Phenotype data: Included
Data use policy: NBDC data sharing policy (JGAP000001)