Dataset ID

NHA000203

Name: NHA000203: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Published: 2025-10-27

Type of data: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Access criteria: Unrestricted-access
Total data volume: 1.2 TB
File formats: TXT
XLSX
Research: hum0197
Date published: 2025-10-27
Date modified: 2025-10-27
Secondary ID: hum0197.v26.374-traits.v1

Unrestricted-access files linked to this dataset

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6301–6400 / 8930

File	Label	Size	Copy URL
UKB1.metabolome.L_VLDL_FC_by_CE.Vegetable_and_fish.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_FC_pct.Age.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_FC_pct.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_FC_pct.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_FC_pct.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_FC_pct.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_FC_pct.Joint_all_environments.txt.gz		179 MB
UKB1.metabolome.L_VLDL_FC_pct.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_FC_pct.Meat_and_cheese.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_FC_pct.Physical_activity.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_FC_pct.Sex.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_FC_pct.Tea_and_coffee.txt.gz		77.4 MB
UKB1.metabolome.L_VLDL_FC_pct.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Age.txt.gz		78.5 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Joint_commonly_tested_environments.txt.gz		128 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Meat_and_cheese.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Physical_activity.txt.gz		78.6 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Sex.txt.gz		78.4 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Tea_and_coffee.txt.gz		77.6 MB
UKB1.metabolome.L_VLDL_FC_pct_C.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_L.Age.txt.gz		78.1 MB
UKB1.metabolome.L_VLDL_L.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_L.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_L.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_L.Ever_smoking.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_L.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_L.Joint_commonly_tested_environments.txt.gz		128 MB
UKB1.metabolome.L_VLDL_L.Meat_and_cheese.txt.gz		78.9 MB
UKB1.metabolome.L_VLDL_L.Physical_activity.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_L.Sex.txt.gz		78.4 MB
UKB1.metabolome.L_VLDL_L.Tea_and_coffee.txt.gz		77.6 MB
UKB1.metabolome.L_VLDL_L.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_P.Age.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_P.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_P.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_P.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_P.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_P.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_P.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_P.Meat_and_cheese.txt.gz		78.9 MB
UKB1.metabolome.L_VLDL_P.Physical_activity.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_P.Sex.txt.gz		78.4 MB
UKB1.metabolome.L_VLDL_P.Tea_and_coffee.txt.gz		77.6 MB
UKB1.metabolome.L_VLDL_P.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_PL.Age.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_PL.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_PL.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_PL.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_PL.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_PL.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_PL.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_PL.Meat_and_cheese.txt.gz		78.9 MB
UKB1.metabolome.L_VLDL_PL.Physical_activity.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_PL.Sex.txt.gz		78.6 MB
UKB1.metabolome.L_VLDL_PL.Tea_and_coffee.txt.gz		77.7 MB
UKB1.metabolome.L_VLDL_PL.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_PL_pct.Age.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_PL_pct.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_PL_pct.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_PL_pct.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_PL_pct.Ever_smoking.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_PL_pct.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_PL_pct.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_PL_pct.Meat_and_cheese.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_PL_pct.Physical_activity.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_PL_pct.Sex.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_PL_pct.Tea_and_coffee.txt.gz		77.5 MB
UKB1.metabolome.L_VLDL_PL_pct.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_TG.Age.txt.gz		78.4 MB
UKB1.metabolome.L_VLDL_TG.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_TG.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_TG.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_TG.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_TG.Joint_all_environments.txt.gz		178 MB
UKB1.metabolome.L_VLDL_TG.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_TG.Meat_and_cheese.txt.gz		78.9 MB
UKB1.metabolome.L_VLDL_TG.Physical_activity.txt.gz		78.6 MB
UKB1.metabolome.L_VLDL_TG.Sex.txt.gz		78.1 MB
UKB1.metabolome.L_VLDL_TG.Tea_and_coffee.txt.gz		77.4 MB
UKB1.metabolome.L_VLDL_TG.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.L_VLDL_TG_pct.Age.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_TG_pct.Combined.txt.gz		47.8 MB
UKB1.metabolome.L_VLDL_TG_pct.Current_smoking.txt.gz		78.7 MB
UKB1.metabolome.L_VLDL_TG_pct.Ever_drinking.txt.gz		78.3 MB
UKB1.metabolome.L_VLDL_TG_pct.Ever_smoking.txt.gz		79.1 MB
UKB1.metabolome.L_VLDL_TG_pct.Joint_all_environments.txt.gz		179 MB
UKB1.metabolome.L_VLDL_TG_pct.Joint_commonly_tested_environments.txt.gz		129 MB
UKB1.metabolome.L_VLDL_TG_pct.Meat_and_cheese.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_TG_pct.Physical_activity.txt.gz		78.8 MB
UKB1.metabolome.L_VLDL_TG_pct.Sex.txt.gz		78.5 MB
UKB1.metabolome.L_VLDL_TG_pct.Tea_and_coffee.txt.gz		77.6 MB
UKB1.metabolome.L_VLDL_TG_pct.Vegetable_and_fish.txt.gz		79.0 MB
UKB1.metabolome.Lactate.Age.txt.gz		78.4 MB
UKB1.metabolome.Lactate.Combined.txt.gz		47.8 MB
UKB1.metabolome.Lactate.Current_smoking.txt.gz		78.7 MB

6301–6400 / 8930

Analysis method

genome wide SNPs

Materials and participants: BioBank Japan (n=166,757), UK Biobank (n=273,453)
(ICD 10: E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J30.2)
no. Phenotypes: 374; Health status
Mixed
Subject count
440,210 (Individual)
Cohort
BioBank Japan, UK Biobank
Population
British, Japanese
Disease: Type 2 diabetes mellitus
Sample description: DNAs extracted from peripheral blood cells; Tissue
Peripheral blood
Tumor / normal
Normal
Sample provider: N/A
Experimental method: Genotyping by array
Target: N/A
Reagent kit: HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform: Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
QC and filtering: Clinical Phenotypes: imputation quality > 0.7, minor allele frequency (MAF) > 0.01, autosomal variants
Metabolome: further restricted to (i) genotyped variants, (ii) HapMap3 variants, and (iii) the variants with P_G×E < 1.0×10^-7 in BBJ or UKBB for at least one of the clinical traits
Imputation: BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
Analysis method: GEM
Variant count: BBJ: 7,444,735 (Clinical traits)
1,009,566 (Metabolome)
UK Biobank: 9,813,264 (Clinical traits)
1,478,430 (Metabolome)
Phenotype data: Included
Data use policy: NBDC data sharing policy (JGAP000001)