Dataset ID

NHA000203

Name: NHA000203: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Published: 2025-10-27

Type of data: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Access criteria: Unrestricted-access
Total data volume: 1.2 TB
File formats: TXT
XLSX
Research: hum0197
Date published: 2025-10-27
Date modified: 2025-10-27
Secondary ID: hum0197.v26.374-traits.v1

Unrestricted-access files linked to this dataset

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3101–3200 / 8930

File	Label	Size	Copy URL
BBJ1.metabolome.S_VLDL_CE.European_cuisine.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_CE.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_CE.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_CE.Japanese_cuisine_Washoku.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_CE.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.S_VLDL_CE.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_CE.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE_pct.Age.txt.gz		53.2 MB
BBJ1.metabolome.S_VLDL_CE_pct.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_CE_pct.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_CE_pct.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_CE_pct.European_cuisine.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_CE_pct.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_CE_pct.Ever_smoking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_CE_pct.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_CE_pct.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_CE_pct.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.S_VLDL_CE_pct.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_CE_pct.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Age.txt.gz		53.0 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Dairy_products.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Japanese_cuisine_Washoku.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Physical_activity.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_CE_pct_C.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_C_pct.Age.txt.gz		53.2 MB
BBJ1.metabolome.S_VLDL_C_pct.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_C_pct.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_C_pct.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_C_pct.European_cuisine.txt.gz		53.4 MB
BBJ1.metabolome.S_VLDL_C_pct.Ever_drinking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_C_pct.Ever_smoking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_C_pct.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_C_pct.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_C_pct.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.S_VLDL_C_pct.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_C_pct.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC.Age.txt.gz		53.0 MB
BBJ1.metabolome.S_VLDL_FC.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_FC.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_FC.European_cuisine.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_FC.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_FC.Joint_commonly_tested_environments.txt.gz		86.5 MB
BBJ1.metabolome.S_VLDL_FC.Physical_activity.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Age.txt.gz		52.8 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Current_smoking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Dairy_products.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Physical_activity.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_by_CE.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct.Age.txt.gz		53.1 MB
BBJ1.metabolome.S_VLDL_FC_pct.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_FC_pct.Current_smoking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Dairy_products.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct.European_cuisine.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_FC_pct.Ever_drinking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Ever_smoking.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_FC_pct.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC_pct.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_FC_pct.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.S_VLDL_FC_pct.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_FC_pct.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Age.txt.gz		52.9 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Dairy_products.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Japanese_cuisine_Washoku.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Joint_all_environments.txt.gz		120 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Joint_commonly_tested_environments.txt.gz		86.4 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Physical_activity.txt.gz		53.5 MB
BBJ1.metabolome.S_VLDL_FC_pct_C.Sex.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_L.Age.txt.gz		52.8 MB
BBJ1.metabolome.S_VLDL_L.Combined.txt.gz		32.3 MB
BBJ1.metabolome.S_VLDL_L.Current_smoking.txt.gz		53.7 MB
BBJ1.metabolome.S_VLDL_L.Dairy_products.txt.gz		53.8 MB
BBJ1.metabolome.S_VLDL_L.European_cuisine.txt.gz		53.6 MB
BBJ1.metabolome.S_VLDL_L.Ever_drinking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_L.Ever_smoking.txt.gz		53.9 MB
BBJ1.metabolome.S_VLDL_L.Japanese_cuisine_Washoku.txt.gz		53.7 MB

3101–3200 / 8930

Analysis method

genome wide SNPs

Materials and participants: BioBank Japan (n=166,757), UK Biobank (n=273,453)
(ICD 10: E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J30.2)
no. Phenotypes: 374; Health status
Mixed
Subject count
440,210 (Individual)
Cohort
BioBank Japan, UK Biobank
Population
British, Japanese
Disease: Type 2 diabetes mellitus (E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J302)
Sample description: DNAs extracted from peripheral blood cells; Tissue
Peripheral blood
Tumor / normal
Normal
Sample provider: N/A
Experimental method: Genotyping by array
Target: N/A
Reagent kit: HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform: Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
QC and filtering: Clinical Phenotypes: imputation quality > 0.7, minor allele frequency (MAF) > 0.01, autosomal variants
Metabolome: further restricted to (i) genotyped variants, (ii) HapMap3 variants, and (iii) the variants with P_G×E < 1.0×10^-7 in BBJ or UKBB for at least one of the clinical traits
Imputation: BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
Analysis method: GEM
Variant count: BBJ: 7,444,735 (Clinical traits)
1,009,566 (Metabolome)
UK Biobank: 9,813,264 (Clinical traits)
1,478,430 (Metabolome)
Phenotype data: Included
Data use policy: NBDC data sharing policy (JGAP000001)