Dataset ID

NHA000203

Name: NHA000203: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Published: 2025-10-27

Type of data: Genome-wide gene-environment interaction studies for clinical traits and metabolites (374 phenotypes)
Access criteria: Unrestricted-access
Total data volume: 1.2 TB
File formats: TXT
XLSX
Research: hum0197
Date published: 2025-10-27
Date modified: 2025-10-27
Secondary ID: hum0197.v26.374-traits.v1

Unrestricted-access files linked to this dataset

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File	Label	Size	Copy URL
BBJ1.clinical.ALP.Age.txt.gz		398 MB
BBJ1.clinical.ALP.Combined.txt.gz		230 MB
BBJ1.clinical.ALP.Current_smoking.txt.gz		397 MB
BBJ1.clinical.ALP.Dairy_products.txt.gz		397 MB
BBJ1.clinical.ALP.European_cuisine.txt.gz		397 MB
BBJ1.clinical.ALP.Ever_drinking.txt.gz		398 MB
BBJ1.clinical.ALP.Ever_smoking.txt.gz		398 MB
BBJ1.clinical.ALP.Japanese_cuisine_Washoku.txt.gz		397 MB
BBJ1.clinical.ALP.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.ALP.Joint_commonly_tested_environments.txt.gz		816 MB
BBJ1.clinical.ALP.Physical_activity.txt.gz		397 MB
BBJ1.clinical.ALP.Sex.txt.gz		398 MB
BBJ1.clinical.ALT.Age.txt.gz		397 MB
BBJ1.clinical.ALT.Combined.txt.gz		230 MB
BBJ1.clinical.ALT.Current_smoking.txt.gz		397 MB
BBJ1.clinical.ALT.Dairy_products.txt.gz		398 MB
BBJ1.clinical.ALT.European_cuisine.txt.gz		397 MB
BBJ1.clinical.ALT.Ever_drinking.txt.gz		397 MB
BBJ1.clinical.ALT.Ever_smoking.txt.gz		397 MB
BBJ1.clinical.ALT.Japanese_cuisine_Washoku.txt.gz		398 MB
BBJ1.clinical.ALT.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.ALT.Joint_commonly_tested_environments.txt.gz		815 MB
BBJ1.clinical.ALT.Physical_activity.txt.gz		398 MB
BBJ1.clinical.ALT.Sex.txt.gz		397 MB
BBJ1.clinical.AST.Age.txt.gz		398 MB
BBJ1.clinical.AST.Combined.txt.gz		230 MB
BBJ1.clinical.AST.Current_smoking.txt.gz		397 MB
BBJ1.clinical.AST.Dairy_products.txt.gz		398 MB
BBJ1.clinical.AST.European_cuisine.txt.gz		398 MB
BBJ1.clinical.AST.Ever_drinking.txt.gz		398 MB
BBJ1.clinical.AST.Ever_smoking.txt.gz		398 MB
BBJ1.clinical.AST.Japanese_cuisine_Washoku.txt.gz		398 MB
BBJ1.clinical.AST.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.AST.Joint_commonly_tested_environments.txt.gz		817 MB
BBJ1.clinical.AST.Physical_activity.txt.gz		398 MB
BBJ1.clinical.AST.Sex.txt.gz		398 MB
BBJ1.clinical.Alb.Age.txt.gz		398 MB
BBJ1.clinical.Alb.Combined.txt.gz		230 MB
BBJ1.clinical.Alb.Current_smoking.txt.gz		397 MB
BBJ1.clinical.Alb.Dairy_products.txt.gz		397 MB
BBJ1.clinical.Alb.European_cuisine.txt.gz		396 MB
BBJ1.clinical.Alb.Ever_drinking.txt.gz		397 MB
BBJ1.clinical.Alb.Ever_smoking.txt.gz		397 MB
BBJ1.clinical.Alb.Japanese_cuisine_Washoku.txt.gz		397 MB
BBJ1.clinical.Alb.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.Alb.Joint_commonly_tested_environments.txt.gz		815 MB
BBJ1.clinical.Alb.Physical_activity.txt.gz		397 MB
BBJ1.clinical.Alb.Sex.txt.gz		397 MB
BBJ1.clinical.Arrhythmia.Age.txt.gz		393 MB
BBJ1.clinical.Arrhythmia.Combined.txt.gz		230 MB
BBJ1.clinical.Arrhythmia.Current_smoking.txt.gz		393 MB
BBJ1.clinical.Arrhythmia.Dairy_products.txt.gz		394 MB
BBJ1.clinical.Arrhythmia.European_cuisine.txt.gz		393 MB
BBJ1.clinical.Arrhythmia.Ever_drinking.txt.gz		393 MB
BBJ1.clinical.Arrhythmia.Ever_smoking.txt.gz		393 MB
BBJ1.clinical.Arrhythmia.Japanese_cuisine_Washoku.txt.gz		394 MB
BBJ1.clinical.Arrhythmia.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.Arrhythmia.Joint_commonly_tested_environments.txt.gz		806 MB
BBJ1.clinical.Arrhythmia.Physical_activity.txt.gz		394 MB
BBJ1.clinical.Arrhythmia.Sex.txt.gz		393 MB
BBJ1.clinical.Asthma.Age.txt.gz		393 MB
BBJ1.clinical.Asthma.Combined.txt.gz		230 MB
BBJ1.clinical.Asthma.Current_smoking.txt.gz		393 MB
BBJ1.clinical.Asthma.Dairy_products.txt.gz		393 MB
BBJ1.clinical.Asthma.European_cuisine.txt.gz		393 MB
BBJ1.clinical.Asthma.Ever_drinking.txt.gz		393 MB
BBJ1.clinical.Asthma.Ever_smoking.txt.gz		393 MB
BBJ1.clinical.Asthma.Japanese_cuisine_Washoku.txt.gz		393 MB
BBJ1.clinical.Asthma.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.Asthma.Joint_commonly_tested_environments.txt.gz		804 MB
BBJ1.clinical.Asthma.Physical_activity.txt.gz		393 MB
BBJ1.clinical.Asthma.Sex.txt.gz		393 MB
BBJ1.clinical.BMI.Age.txt.gz		401 MB
BBJ1.clinical.BMI.Combined.txt.gz		230 MB
BBJ1.clinical.BMI.Current_smoking.txt.gz		401 MB
BBJ1.clinical.BMI.Dairy_products.txt.gz		402 MB
BBJ1.clinical.BMI.European_cuisine.txt.gz		401 MB
BBJ1.clinical.BMI.Ever_drinking.txt.gz		400 MB
BBJ1.clinical.BMI.Ever_smoking.txt.gz		401 MB
BBJ1.clinical.BMI.Japanese_cuisine_Washoku.txt.gz		402 MB
BBJ1.clinical.BMI.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.BMI.Joint_commonly_tested_environments.txt.gz		825 MB
BBJ1.clinical.BMI.Physical_activity.txt.gz		402 MB
BBJ1.clinical.BMI.Sex.txt.gz		400 MB
BBJ1.clinical.BS.Age.txt.gz		398 MB
BBJ1.clinical.BS.Combined.txt.gz		230 MB
BBJ1.clinical.BS.Current_smoking.txt.gz		397 MB
BBJ1.clinical.BS.Dairy_products.txt.gz		398 MB
BBJ1.clinical.BS.European_cuisine.txt.gz		396 MB
BBJ1.clinical.BS.Ever_drinking.txt.gz		398 MB
BBJ1.clinical.BS.Ever_smoking.txt.gz		398 MB
BBJ1.clinical.BS.Japanese_cuisine_Washoku.txt.gz		399 MB
BBJ1.clinical.BS.Joint_all_environments.txt.gz		1.2 GB
BBJ1.clinical.BS.Joint_commonly_tested_environments.txt.gz		818 MB
BBJ1.clinical.BS.Physical_activity.txt.gz		398 MB
BBJ1.clinical.BS.Sex.txt.gz		398 MB
BBJ1.clinical.BUN.Age.txt.gz		392 MB
BBJ1.clinical.BUN.Combined.txt.gz		230 MB
BBJ1.clinical.BUN.Current_smoking.txt.gz		393 MB
BBJ1.clinical.BUN.Dairy_products.txt.gz		393 MB

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Analysis method

genome wide SNPs

Materials and participants: BioBank Japan (n=166,757), UK Biobank (n=273,453)
(ICD 10: E11, I20, I21, I22, I23, I24, I25, I44, I45, I46, I47, I48, I49, E78, I60, I61, I62, I63, I64, H25, H26, H28, J45, J46, N20, N21, N22, J30.2)
no. Phenotypes: 374; Health status
Mixed
Subject count
440,210 (Individual)
Cohort
BioBank Japan, UK Biobank
Population
British, Japanese
Disease: Type 2 diabetes mellitus
Sample description: DNAs extracted from peripheral blood cells; Tissue
Peripheral blood
Tumor / normal
Normal
Sample provider: N/A
Experimental method: Genotyping by array
Target: N/A
Reagent kit: HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform: Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
QC and filtering: Clinical Phenotypes: imputation quality > 0.7, minor allele frequency (MAF) > 0.01, autosomal variants
Metabolome: further restricted to (i) genotyped variants, (ii) HapMap3 variants, and (iii) the variants with P_G×E < 1.0×10^-7 in BBJ or UKBB for at least one of the clinical traits
Imputation: BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
Analysis method: GEM
Variant count: BBJ: 7,444,735 (Clinical traits)
1,009,566 (Metabolome)
UK Biobank: 9,813,264 (Clinical traits)
1,478,430 (Metabolome)
Phenotype data: Included
Data use policy: NBDC data sharing policy (JGAP000001)