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Dataset ID

NHA000162

Type of data
GWAS for 215 phenotypes
Access criteria
Unrestricted-access
Total data volume
567 GB
File formats
  • HTML
  • ZIP
Research
hum0197
Date published
2021-03-22
Date modified
2021-03-22
Secondary ID
hum0197.v3.gwas.v1

Unrestricted-access files linked to this dataset

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51–100 / 601

FileLabelSizeCopy URL
hum0197.v3.BBJ.CHF.v1.zipDisease name: Chronic heart failure / Abbreviation: CHF / ICD10: I50.01.6 GB
hum0197.v3.BBJ.CL.v1.zipDisease name: Cholelithiasis / Abbreviation: Cholelithiasis / ICD10: K801.6 GB
hum0197.v3.BBJ.COPD.v1.zipDisease name: Chronic obstructive pulmonary disease / Abbreviation: COPD / ICD10: J441.6 GB
hum0197.v3.BBJ.CP.v1.zipDisease name: Colon polyp / Abbreviation: Colon_polyp / ICD10: K63.51.6 GB
hum0197.v3.BBJ.CRF.v1.zipDisease name: Chronic renal failure / Abbreviation: Chronic_Renal_Failure / ICD10: N181.6 GB
hum0197.v3.BBJ.CRP.v1.zipCategory: Inflammatory / Trait name: C-reactive protein / Abbreviation: CRP591 MB
hum0197.v3.BBJ.CS.v1.zipDisease name: Cesarian section / Abbreviation: C_sec / ICD10: O821.5 GB
hum0197.v3.BBJ.CSOM.v1.zipDisease name: Chronic suppurative otitis media / Abbreviation: CSOM / ICD10: H66.1/H66.21.6 GB
hum0197.v3.BBJ.CTS.v1.zipDisease name: Carpal tunnel syndrome / Abbreviation: Carpal_Tunnel_Syndrome / ICD10: G56.01.5 GB
hum0197.v3.BBJ.CVD.v1.zipDisease name: Cardiac valvular disease / Abbreviation: Cardiac_Valvular_Disease / ICD10: I34/I351.6 GB
hum0197.v3.BBJ.Ca.v1.zipCategory: Electrolytes / Trait name: Calcium / Abbreviation: Ca591 MB
hum0197.v3.BBJ.Car.v1.zipDisease name: Cardiomegaly / Abbreviation: Cardiomegaly / ICD10: I51.71.6 GB
hum0197.v3.BBJ.Cat.v1.zipDisease name: Cataract / Abbreviation: Cataract / ICD10: H25/H261.6 GB
hum0197.v3.BBJ.CeAn.v1.zipDisease name: Cerebral aneurysm / Abbreviation: CeAn / ICD10: I67.11.6 GB
hum0197.v3.BBJ.CeC.v1.zipDisease name: Cervical cancer / Abbreviation: CeC / ICD10: C531.5 GB
hum0197.v3.BBJ.ChG.v1.zipDisease name: Chronic glomerulonephritis / Abbreviation: Chronic_Glomerulonephritis / ICD10: N031.5 GB
hum0197.v3.BBJ.ChP.v1.zipDisease name: Chronic pancreatitis / Abbreviation: Chronic_Pancreatitis / ICD10: K861.6 GB
hum0197.v3.BBJ.ChS.v1.zipDisease name: Chronic sinusitis / Abbreviation: Chronic_Sinusitis / ICD10: J321.6 GB
hum0197.v3.BBJ.Cho.v1.zipDisease name: Cholecystitis / Abbreviation: Cholecystitis / ICD10: K80.0/K80.1/K80.4/K811.6 GB
hum0197.v3.BBJ.Cir.v1.zipDisease name: Cirrhosis / Abbreviation: Cirrhosis / ICD10: K74.61.6 GB
hum0197.v3.BBJ.Co.v1.zipDisease name: Constipation / Abbreviation: Constipation / ICD10: K59.01.6 GB
hum0197.v3.BBJ.Cys.v1.zipDisease name: Cystitis / Abbreviation: Cystitis / ICD10: N30.01.6 GB
hum0197.v3.BBJ.DBP.v1.zipCategory: Blood pressure / Trait name: Diastolic blood pressure / Abbreviation: DBP591 MB
hum0197.v3.BBJ.DC.v1.zipDisease name: Dilated cardiomyopathy / Abbreviation: Dilated_Cardiomyopathy / ICD10: I42.01.5 GB
hum0197.v3.BBJ.DN.v1.zipDisease name: Diabetic nephropathy / Abbreviation: DM_Nephropathy / ICD10: E11.21.5 GB
hum0197.v3.BBJ.Dep.v1.zipDisease name: Depression / Abbreviation: Depression / ICD10: F331.6 GB
hum0197.v3.BBJ.Dip.v1.zipDisease name: Diphtheria infection / Abbreviation: Diphtheria / ICD10: A361.5 GB
hum0197.v3.BBJ.Dys.v1.zipDisease name: Dysentery / Abbreviation: Dysentery / ICD10: A03.91.6 GB
hum0197.v3.BBJ.EC.v1.zipDisease name: Esophageal cancer / Abbreviation: EsC / ICD10: C151.6 GB
hum0197.v3.BBJ.EM.v1.zipDisease name: Endometriosis / Abbreviation: Endometriosis / ICD10: N801.6 GB
hum0197.v3.BBJ.EOS.v1.zipCategory: Blood cell / Trait name: Eosinophil / Abbreviation: EOS591 MB
hum0197.v3.BBJ.EV.v1.zipDisease name: Esophageal varix / Abbreviation: Esophageal_varix / ICD10: I851.5 GB
hum0197.v3.BBJ.EcP.v1.zipDisease name: Ectopic pregnancy / Abbreviation: Ect_preg / ICD10: O001.5 GB
hum0197.v3.BBJ.EnC.v1.zipDisease name: Endometrial cancer / Abbreviation: EnC / ICD10: C541.5 GB
hum0197.v3.BBJ.Ep.v1.zipDisease name: Epilepsy / Abbreviation: Epilepsy / ICD10: G40/G411.6 GB
hum0197.v3.BBJ.FA.v1.zipDisease name: Food allergy / Abbreviation: Food_Allergy / ICD10: Z91.011.6 GB
hum0197.v3.BBJ.FNP.v1.zipDisease name: Facial nerve palsy (Bell's palsy) / Abbreviation: FacialN_palsy / ICD10: G51.01.6 GB
hum0197.v3.BBJ.FS.v1.zipDisease name: Febrile seizure / Abbreviation: Febrile_Seizure / ICD10: R56.01.5 GB
hum0197.v3.BBJ.GBP.v1.zipDisease name: Gall bladder polyp / Abbreviation: GB_polyp / ICD10: K82.81.6 GB
hum0197.v3.BBJ.GC.v1.zipDisease name: Gastric cancer / Abbreviation: GaC / ICD10: C161.6 GB
hum0197.v3.BBJ.GD.v1.zipDisease name: Graves' disease / Abbreviation: GD / ICD10: E05.01.6 GB
hum0197.v3.BBJ.GERD.v1.zipDisease name: Gastroesophageal reflux disease / Abbreviation: GERD / ICD10: K211.6 GB
hum0197.v3.BBJ.GGT.v1.zipCategory: Liver-related / Trait name: γ-glutamyl transpeptidase / Abbreviation: GGT592 MB
hum0197.v3.BBJ.GP.v1.zipDisease name: Gastric polyp / Abbreviation: Gastric_polyp / ICD10: K31.71.6 GB
hum0197.v3.BBJ.GU.v1.zipDisease name: Gastric ulcer / Abbreviation: Gastric_Ulcer / ICD10: K251.6 GB
hum0197.v3.BBJ.Gla.v1.zipDisease name: Glaucoma / Abbreviation: Glaucoma / ICD10: H401.6 GB
hum0197.v3.BBJ.Glucose.v1.zipCategory: Metabolic / Trait name: Glucose / Abbreviation: Glucose591 MB
hum0197.v3.BBJ.Goi.v1.zipDisease name: Goiter / Abbreviation: Goiter / ICD10: E041.6 GB
hum0197.v3.BBJ.H03A.v1.zipATC-category: H03A / Description: Thyroid preparations1.5 GB
hum0197.v3.BBJ.HAV.v1.zipDisease name: Acute hepatitis by Hepatitis A virus / Abbreviation: HAV_hepatitis / ICD10: B15.91.5 GB

51–100 / 601

Analysis method

genome wide SNPs

Materials and participants
Biobank Japan (n = 179,000), UK biobank (n = 361,000), FinnGen (n = 136,000), no. Phenotypes: 220
  • Health status
    Mixed
  • Subject count
    676,000 (Individual)
  • Cohort
    BioBank Japan, FinnGen, UK Biobank
  • Population
    British, Finnish, Japanese
Sample description
DNAs extracted from peripheral blood cells
  • Tissue
    Peripheral blood
  • Tumor / normal
    Normal
Sample provider
N/A
Experimental method
Genotyping by array
Target
N/A
Reagent kit
FinnGen1 ThermoFisher Array
HumanExome BeadChip Kit
HumanOmniExpress BeadChip Kit
HumanOmniExpressExome BeadChip Kit
UK BiLEVE Axiom Array
UK Biobank Axiom Array
Platform
Applied Biosystems UK BiLEVE Axiom Array
Applied Biosystems UK Biobank Axiom Array
Illumina HumanExome
Illumina HumanOmniExpress
Illumina HumanOmniExpressExome
Thermo Fisher Scientific FinnGen1 ThermoFisher Array
QC and filtering
BBJ: We included imputed variants with Rsq > 0.7.
UK Biobank: We excluded the variants with (i) INFO score ≤ 0.8, (ii) MAF ≤ 0.0001 (except for missense and protein-truncating variants annotated by VEP, which were excluded if MAF ≤ 1 × 10-6), and (iii) PHWE ≤ 1 × 10-10.
FinnGen: We excluded variants with an imputation INFO score < 0.8 or MAF < 0.0001.
Imputation
BBJ: Eagle, Minimac3
UK Biobank: IMPUTE4
FinnGen: beagle4.1
Analysis method
For binary traits, SAIGE software was used with age, age2, sex, age×sex, age2×sex, and top 20 principal components as covariates. For quantitative traits (biomarkers), BOLT-LMM or plink software was used with the same covariates.
Variant count
BBJ: 13,530,797 variants
UK Biobank: 13,791,467 variants
FinnGen: 16,859,359 variants
Phenotype data
Included
Data use policy
NBDC data sharing policy (JGAP000001)