NBDC Research ID: hum0140.v1

 

SUMMARY

Aims: Establishment of novel prediction method of preoperative chemoradiothearpeutic effect based on the molecular profiling in rectal cancer patients

Methods: Exome analysis by using Illumina Hiseq 2000

Participants/Materials: 74 rectal cancer patients treated with preoperative chemoraidotherapy

 

Dataset IDType of DataCriteriaRelease Date
JGAS000158 NGS (Exome) Controlled-access (Type I) 2019/11/19

*Release Note 

* Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more

 

MOLECULAR DATA

JGAS000158

Participants/Materials 74 rectal cancer (ICD10: C20 [NG80]) treated with preoperative chemoraidotherapy
Targets Exome
Target Loci for Capture Methods -
Platform Illumina [HiSeq 2000]
Library Source DNAs extracted from non-tumor tissues (or peripheral blood cells as normal tissues)  and the primary tumor tissues
Cell Lines -
Library Construction (kit name)

SureSelect Custom(v5n) or SureSelect Custom(v5)

    - v5n: SureSelect Human All Exon V5 + lincRNA + Virus

    - v5: SureSelect Human All Exon V5 + lincRNA

Fragmentation Methods Ultrasonic fragmentation
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 200 bp
Japanese Genotype-phenotype Archive Dataset ID JGAD000236
Total Data Volume 2 TB (fastq)
Comments (Policies) NBDC policy

 

DATA PROVIDER

Principal Investigator: Takashi Akiyoshi

Affiliation: The Cancer Institute Hospital of JFCR

Project / Group Name: -

Funds / Grants (Research Project Number):

Name Title Project Number
KAKENHI Grant-in-Aid for Scientific Research (C) Genomic Profile of Responders to Preoperative Chemoradiotherapy for Advanced Rectal Cancer 15K10156

 

PUBLICATIONS

TitleDOIDataset ID
1 Immunogenomic profiles associated with response to neoadjuvant chemoradiotherapy in patients with rectal cancer. doi: 10.1002/bjs.11179 JGAD000236
2

 

USERS (Controlled-access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use
Kouya Shiraishi Division of Genome Biology, National Cancer Research Institute Elucidation of immune-system networks between host and tumor based on genomic analysis JGAD000236 2020/09/18-2023/03/31